EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany; Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany.
EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany.
Trends Biochem Sci. 2022 Dec;47(12):993-995. doi: 10.1016/j.tibs.2022.07.008. Epub 2022 Aug 13.
Cofactors are essential effectors of the transcription control machinery. How this functionally diverse group of factors is used in the genome remains elusive. A recent study by Neumayr, Haberle et al. sheds light on this question, showing that enhancers depend on defined combinations of cofactors for their activation.
辅助因子是转录调控机制的必需效应因子。这个功能多样的因子群体在基因组中是如何被利用的仍然难以捉摸。最近由 Neumayr、Haberle 等人进行的一项研究揭示了这个问题，表明增强子的激活依赖于特定组合的辅助因子。
