Okşul Metin, Şener Yusuf Ziya, Sarıkaya Yasin, Sarıkaya Sevtap, Yıldırım Arzu, Canpolat Uğur, Akpınar Meltem Gülsün, Hazırolan Tuncay, Özer Necla, Tokgözoğlu Sadberk Lale
Cardiology Department, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
Cardiology Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Ir J Med Sci. 2023 Apr;192(2):625-631. doi: 10.1007/s11845-022-03127-2. Epub 2022 Aug 16.
Atherosclerotic cardiovascular disease is still the leading cause of mortality for women. Breast cancer screening with mammography is recommended in all women aged over 40 years.
Whether breast artery calcification (BAC) is associated with cardiovascular disease is not clear. We aimed to evaluate the association between BAC and the presence of coronary atherosclerosis determined by CT.
All patients who underwent both mammography and coronary CT angiography between January 2010 and December 2016 were screened, and patients with a duration of less than 12 months between CT and mammography were included.
A total of 320 women were included and BAC was detected in 47 (14.6%) patients. BAC was correlated with age and CT coronary calcium score. Both the frequency of critical coronary artery stenosis (34% vs 10.6%; p = 0.001) and CT coronary calcium score (5.5 vs 0; p = 0.001) was significantly higher in patients with BAC. The absence of BAC was a strong predictor of the absence of significant coronary artery disease (p = 0.001). BAC was independently associated with all-cause mortality after excluding patients with breast cancer (HR: 5.32; p = 0.013).
Breast artery calcification is associated with coronary calcium score and significant coronary stenosis. A high BAC score is related to increased mortality.
动脉粥样硬化性心血管疾病仍是女性死亡的主要原因。建议所有40岁以上女性进行乳腺钼靶筛查。
乳腺动脉钙化（BAC）是否与心血管疾病相关尚不清楚。我们旨在评估BAC与CT确定的冠状动脉粥样硬化之间的关联。
筛选2010年1月至2016年12月期间同时接受乳腺钼靶和冠状动脉CT血管造影的所有患者，纳入CT和乳腺钼靶检查间隔时间少于12个月的患者。
共纳入320名女性，47名（14.6%）患者检测到BAC。BAC与年龄和CT冠状动脉钙化评分相关。BAC患者的严重冠状动脉狭窄发生率（34%对10.6%；p = 0.001）和CT冠状动脉钙化评分（5.5对0；p = 0.001）均显著更高。未检测到BAC是无显著冠状动脉疾病的有力预测指标（p = 0.001）。排除乳腺癌患者后，BAC与全因死亡率独立相关（HR：5.32；p = 0.013）。
乳腺动脉钙化与冠状动脉钙化评分和显著冠状动脉狭窄相关。高BAC评分与死亡率增加有关。
