台湾阿卡斑病毒的分子流行病学研究。
Molecular epidemiology of Akabane virus in Taiwan.
机构信息
Department of Entomology, National Chung Hsing University, Taichung City, Taiwan.
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung City, Taiwan.
出版信息
Vet Med Sci. 2022 Sep;8(5):2215-2222. doi: 10.1002/vms3.887. Epub 2022 Aug 16.
BACKGROUND
Akabane virus (AKAV) is a teratogenic and neuropathogenic arbovirus that infects livestock and wild animals. AKAVs are endemic arboviruses from dairy farms in Taiwan in 1989, and the first sequence was detected in cattle with nonsuppurative encephalitis in 1992.
OBJECTIVES
This study aims to understand the epidemiological relationships of the akabane viruses between Taiwan and nearby places.
METHODS
In this study, 17 specimens were identified or isolated from vector insects, and ruminant fetuses collected from 1992 to 2015 were sequenced and analysed.
RESULTS
Sequence analyses revealed all Taiwanese AKAVs belonged to genogroup Ia but diverged into two clusters in the phylogenetic trees, implying that at least two invasive events of AKAV may have occurred in Taiwan.
CONCLUSIONS
The two clusters of AKAVs could still be identified in Taiwan in 2015, and a reassortment event was observed, indicating that the two clusters of AKAVs are already endemic in Taiwan.
背景
阿卡斑病毒（AKAV）是一种致畸和神经致病性虫媒病毒，感染家畜和野生动物。1989 年，台湾的奶牛场出现了地方性虫媒病毒 AKAV，1992 年首次在患有非化脓性脑炎的牛中检测到该病毒的第一个序列。
目的
本研究旨在了解台湾及其周边地区阿卡斑病毒之间的流行病学关系。
方法
本研究从媒介昆虫中鉴定或分离出 17 个标本，并对 1992 年至 2015 年采集的反刍动物胎儿进行了测序和分析。
结果
序列分析显示，所有台湾 AKAV 均属于基因群 Ia，但在系统进化树上分为两个聚类，表明 AKAV 至少有两次入侵事件发生在台湾。
结论
2015 年仍可在台湾检测到两群 AKAV，且观察到重组事件，表明两群 AKAV 已在台湾流行。
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