Zhang Zhu-Zhu, Lei Jia-Jia, Zhang Xiao-Hong, Zhang Xing-Guo, Tu Hai-Yong
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization, Hezhou University, Hezhou 542899, China.
Org Lett. 2022 Aug 26;24(33):6192-6196. doi: 10.1021/acs.orglett.2c02464. Epub 2022 Aug 16.
A Ni-catalyzed three-component reductive fluoroalkylacylation of alkynes with fluoroalkyl halides and acyl chlorides is presented. This dicarbofunctionalization provides an efficient method for the synthesis of fluoroalkyl-incorporated enones under mild conditions with high yields and excellent regioselectivity and stereoselectivity.
本文报道了一种镍催化的炔烃与氟代烷基卤化物和酰氯的三组分还原氟代烷基酰化反应。这种双碳官能化反应提供了一种在温和条件下高效合成含氟代烷基烯酮的方法，产率高，区域选择性和立体选择性优异。
