镍催化炔烃的还原氟烷基酰化反应用于氟烷基化烯酮的立体选择性合成
Ni-Catalyzed Reductive Fluoroalkylacylation of Alkynes for the Steroselective Synthesis of Fluoroalkylated Enones.
作者信息
Zhang Zhu-Zhu, Lei Jia-Jia, Zhang Xiao-Hong, Zhang Xing-Guo, Tu Hai-Yong
机构信息
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization, Hezhou University, Hezhou 542899, China.
出版信息
Org Lett. 2022 Aug 26;24(33):6192-6196. doi: 10.1021/acs.orglett.2c02464. Epub 2022 Aug 16.
A Ni-catalyzed three-component reductive fluoroalkylacylation of alkynes with fluoroalkyl halides and acyl chlorides is presented. This dicarbofunctionalization provides an efficient method for the synthesis of fluoroalkyl-incorporated enones under mild conditions with high yields and excellent regioselectivity and stereoselectivity.
本文报道了一种镍催化的炔烃与氟代烷基卤化物和酰氯的三组分还原氟代烷基酰化反应。这种双碳官能化反应提供了一种在温和条件下高效合成含氟代烷基烯酮的方法，产率高，区域选择性和立体选择性优异。
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