Government Medical College, Patiala, Punjab, India.
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway (NH-64), Tehsil, Rajpura District, Patiala, 140401, Punjab, India.
Inflammopharmacology. 2022 Oct;30(5):1843-1851. doi: 10.1007/s10787-022-01049-0. Epub 2022 Aug 16.
Inflammation is a prominent clinical manifestation in type 2 diabetes mellitus (TDM) patients, often associated with insulin resistance, metabolic dysregulation, and other complications.
The present study has been designed to check the serum levels of PAR-1 and correlate with various clinical manifestations and inflammatory cytokines levels in type 2 diabetic subjects.
The study population was divided into two groups, healthy volunteers (n = 15): normal glycated hemoglobin (HbA1c) (4.26 ± 0.55) and type 2 diabetic subjects (n = 30): HbA1c levels (7.80 ± 2.41). The serum levels of PAR-1 (ELISA method) were studied in both groups and correlated with demographic parameters age, weight, body mass index (BMI), and conventional inflammation biomarkers like C-reactive protein (CRP), interleukin 6 (IL-6), interleukin 8 (IL-8), and tumour necrosis factor-alpha (TNF-α).
The demographic variables including the body weight (77.38 ± 10.00 vs. controls 55.26 ± 6.99), BMI (29.39 ± 3.61 vs. controls 25.25 ± 4.01), glycemic index HbA1c (7.80 ± 2.41 vs. controls 4.26 ± 0.55) were found to be statistically increased in TDM subjects than the healthy control group. The levels of various inflammatory biomarkers and PAR-1 were significantly elevated in TDM groups in comparison to healthy volunteers. The univariate and multivariate regression analysis revealed that elevated PAR-1 levels positively correlated with increased body weight, BMI, HbA1c, and inflammatory cytokines.
Our findings indicate that the elevated serum PAR-1 levels serve as an independent predictor of inflammation in TDM subjects and might have prognostic value for determining TDM progression.
炎症是 2 型糖尿病（T2DM）患者的突出临床表现，常与胰岛素抵抗、代谢失调及其他并发症有关。
本研究旨在检查 PAR-1 的血清水平，并与 2 型糖尿病患者的各种临床表现和炎症细胞因子水平相关联。
研究人群分为两组，健康志愿者（n=15）：正常糖化血红蛋白（HbA1c）（4.26±0.55）和 2 型糖尿病患者（n=30）：HbA1c 水平（7.80±2.41）。研究了两组患者的 PAR-1（ELISA 法）血清水平，并与年龄、体重、体重指数（BMI）等人口统计学参数以及 C 反应蛋白（CRP）、白细胞介素 6（IL-6）、白细胞介素 8（IL-8）和肿瘤坏死因子-α（TNF-α）等常规炎症生物标志物相关联。
体重（77.38±10.00 与对照组 55.26±6.99）、BMI（29.39±3.61 与对照组 25.25±4.01）、血糖指数 HbA1c（7.80±2.41 与对照组 4.26±0.55）等人口统计学参数在 T2DM 患者中发现明显高于健康对照组。与健康志愿者相比，T2DM 组的各种炎症生物标志物和 PAR-1 水平显著升高。单因素和多因素回归分析显示，PAR-1 水平升高与体重增加、BMI、HbA1c 和炎症细胞因子呈正相关。
我们的研究结果表明，升高的血清 PAR-1 水平可作为 T2DM 患者炎症的独立预测因子，并可能对预测 T2DM 进展具有预后价值。
