Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou, China.
Virus Genes. 2022 Dec;58(6):584-588. doi: 10.1007/s11262-022-01928-2. Epub 2022 Aug 16.
The zoonotic H7N9 avian influenza virus emerged with the H9N2-origin internal gene cassette. Previous studies have reported that genetic reassortments with H9N2 were common in the first five human H7N9 epidemic waves. However, our latest work found that the circulating high pathogenicity H7N9 virus has established a dominant internal gene cassette and has decreased the frequency of reassortment with H9N2 since 2018. This dominant cassette of H7N9 was distinct from the cocirculating H9N2, although they shared a common ancestor. As a result, we suppose that this dominant cassette may benefit the viral population fitness and promote its continuous circulation in chickens.
高致病性 H7N9 病毒自 2018 年以来建立了一个占主导地位的内部基因盒，减少了与 H9N2 的重组频率，尽管它们有共同的祖先，但与同时循环的 H9N2 不同。因此，我们推测这个占主导地位的基因盒可能有利于病毒种群的适应性，并促进其在鸡群中的持续循环。
