NEAT1：一种新型长非编码 RNA，参与介导 2 型糖尿病及其各种并发症。
NEAT1: A Novel Long Non-coding RNA Involved in Mediating Type 2 Diabetes and its Various Complications.
机构信息
College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, China.
Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges, Yichang, Hubei 443002, China.
出版信息
Curr Pharm Des. 2022;28(16):1342-1350. doi: 10.2174/1381612828666220428093207.
BACKGROUND
Nuclear-enriched abundant transcript 1 (abbreviated as NEAT1) is a long-chain noncoding RNA involved in various physiological and pathological processes. This study aimed to clarify the effect and molecule system of NEAT1 within non-alcoholic fatty liver disease (NAFLD) as well as type 2 diabetes (T2DM).
METHODS
In this review, current studies concerning mechanisms of NEAT1l, in the development of type 2 diabetes and its complications have been summarized and analyzed. Also, we searched the papers based on NEAT1 related to NAFLD. The related studies were obtained through a systematic search of Pubmed.
RESULTS
NEAT1 displays a close correlation with how T2DM occurs and develops, and it was confirmed to be significantly up-regulated in T2DM and its various complications (e.g., diabetics nephropathy, diabetics cardiomyopathy, diabetics retinopathy as well as diabetic neuropathy). Besides, NEAT1 is capable of impacting the occurrence, development and prognosis of NAFLD and T2DM.
CONCLUSION
LncRNA NEAT1 is likely to act as a novel therapeutic target for T2DM and its complications. Moreover, non-alcoholic fatty liver disease is also correlated with NEAT1.
背景
富含核的丰富转录本 1（缩写为 NEAT1）是一种长链非编码 RNA，参与各种生理和病理过程。本研究旨在阐明 NEAT1 在非酒精性脂肪性肝病（NAFLD）和 2 型糖尿病（T2DM）中的作用和分子系统。
方法
在本综述中，总结和分析了目前关于 NEAT1l 在 2 型糖尿病及其并发症发生发展中的作用机制的研究。此外，我们还基于与 NAFLD 相关的 NEAT1 搜索了论文。通过系统搜索 Pubmed 获得相关研究。
结果
NEAT1 与 T2DM 的发生和发展密切相关，并且在 T2DM 及其各种并发症（例如糖尿病肾病、糖尿病心肌病、糖尿病视网膜病变和糖尿病神经病变）中被证实显著上调。此外，NEAT1 能够影响 NAFLD 和 T2DM 的发生、发展和预后。
结论
长链非编码 RNA NEAT1 可能成为 T2DM 及其并发症的新型治疗靶点。此外，非酒精性脂肪性肝病也与 NEAT1 相关。
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