Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Division of Surgery and Interventional Sciences, University College London, London, UK.
Cancer Med. 2023 Feb;12(3):3468-3476. doi: 10.1002/cam4.5132. Epub 2022 Aug 17.
Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between cannabis use and the risk of urological cancers.
We identified 151,945 individuals with information on cannabis use in the UK Biobank from 2006 to 2010. Crude and age-standardized incidence ratios of different urological cancers were evaluated in the entire cohort and subgroups. Cox regression was performed for survival analysis.
Previous use of cannabis was a significant protective factor for renal cell carcinoma (HR = 0.61, 95%CI:0.40-0.93, p = 0.021) and prostate cancer (HR = 0.82, 95%CI:0.73-0.93, p = 0.002) in multivariable analysis. The association between previous cannabis use and both renal cell carcinoma and bladder cancer was only observed in females (HR = 0.42, 95%CI:0.19-0.94, p = 0.034; HR = 0.43, 95%CI:0.21-0.86, p = 0.018) but not in men. There was no significant association between cannabis use and testicular cancer incidence. Mendelian randomization demonstrated a potential causal effect of cannabis use on a lower incidence of renal cell carcinoma.
Previous use of cannabis was associated with a lower risk of bladder cancer, renal cell carcinoma, and prostate cancer. The inverse association between cannabis and both renal cell carcinoma and bladder cancer was only found in females but not in males.
许多欧洲和北美国家已经批准了大麻的使用立法。其对泌尿系统癌症的影响尚不清楚。本研究旨在探讨大麻使用与泌尿系统癌症风险之间的关系。
我们从 2006 年至 2010 年在英国生物银行中确定了 151945 名有大麻使用信息的个体。在整个队列和亚组中评估了不同泌尿系统癌症的粗发病率和年龄标准化发病率比。进行 Cox 回归进行生存分析。
既往使用大麻是肾细胞癌（HR=0.61，95%CI：0.40-0.93，p=0.021）和前列腺癌（HR=0.82，95%CI：0.73-0.93，p=0.002）的显著保护因素在多变量分析中。既往大麻使用与肾细胞癌和膀胱癌之间的关联仅在女性中观察到（HR=0.42，95%CI：0.19-0.94，p=0.034；HR=0.43，95%CI：0.21-0.86，p=0.018），但在男性中没有。大麻使用与睾丸癌发病率之间没有显著关联。孟德尔随机化表明大麻使用与较低的肾细胞癌发生率之间存在潜在的因果关系。
既往使用大麻与膀胱癌、肾细胞癌和前列腺癌的风险降低相关。大麻与肾细胞癌和膀胱癌之间的反比关联仅在女性中发现，而在男性中未发现。
