Health Management Center, General Practice Medical Center, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
West China School of Public Health, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Int Urol Nephrol. 2024 Apr;56(4):1243-1251. doi: 10.1007/s11255-023-03858-w. Epub 2023 Nov 28.
Numerous observational epidemiological studies have reported a bidirectional relationship between periodontitis and urological cancers. However, the causal link between these two phenotypes remains uncertain. This study aimed to examine the bidirectional causal association between periodontitis and four types of urological tumors, specifically kidney cancer (KC), prostate cancer (PC), bladder cancer (BC), and testis cancer (TC).
Based on large-scale genome-wide association study (GWAS) data, we utilized the two-sample Mendelian randomization (MR) approach to evaluate causal relationships between periodontitis and urological cancers. Several MR methods covering various consistency assumptions were applied in this study, including contamination mixture and Robust Adjusted Profile Score to obtain robust results. Summary-level data of individuals with European ancestry were extracted from the UK Biobank, the Kaiser GERA cohorts, and the FinnGen consortium.
Our findings revealed significant positive genetic correlations between periodontitis and kidney cancer (OR 1.287; 95% CI 1.04, 1.594; P = 0.020). We did not find a significant association of periodontitis on prostate cancer, bladder cancer, and testis cancer. In reverse MR, no significant results were observed supporting the effect of urologic cancers on periodontitis (all P > 0.05).
Our study provides the evidence of a potential causal relationship between periodontitis and kidney cancer. However, large-scale studies are warranted to confirm and elucidate the underlying mechanisms of this association.
大量观察性流行病学研究报告了牙周炎和泌尿系统癌症之间存在双向关系。然而，这两种表型之间的因果关系仍不确定。本研究旨在检验牙周炎与四种泌尿系统肿瘤（即肾癌、前列腺癌、膀胱癌和睾丸癌）之间的双向因果关联。
基于大规模全基因组关联研究（GWAS）数据，我们采用两样本孟德尔随机化（MR）方法来评估牙周炎与泌尿系统癌症之间的因果关系。本研究应用了多种涵盖各种一致性假设的 MR 方法，包括污染混合物和稳健调整轮廓评分，以获得稳健的结果。具有欧洲血统个体的汇总水平数据从英国生物银行、凯撒 GERA 队列和芬兰基因联合会中提取。
我们的研究结果表明，牙周炎与肾癌之间存在显著的正遗传相关性（OR 1.287；95%CI 1.04，1.594；P=0.020）。我们没有发现牙周炎与前列腺癌、膀胱癌和睾丸癌之间存在关联。在反向 MR 中，没有观察到支持泌尿系统癌症对牙周炎影响的显著结果（均 P>0.05）。
我们的研究提供了牙周炎和肾癌之间存在潜在因果关系的证据。然而，需要进行大规模研究来证实和阐明这种关联的潜在机制。
