Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Headache. 2014 Feb;54(2):219-34. doi: 10.1111/head.12296.
Individually, both obesity and headache are conditions associated with a substantial personal and societal impact. Recent data support that obesity is comorbid with headache in general and migraine specifically, as well as with certain secondary headache conditions such as idiopathic intracranial hypertension. In the current manuscript, we first briefly review the epidemiology of obesity and common primary and secondary headache disorders individually. This is followed by a systematic review of the general population data evaluating the association between obesity and headache in general, and then obesity and migraine and tension-type headache disorders. Finally, we briefly discuss the data on the association between obesity and a common secondary headache disorder that is associated with obesity, idiopathic intracranial hypertension. Taken together, these data suggest that it is important for clinicians and patients to be aware of the headache/migraine-obesity association, given that it is potentially modifiable. Hypotheses for mechanisms of the obesity-migraine association and treatment considerations for overweight and obese headache sufferers are discussed in the companion manuscript, as part II of this topic.
单独来看，肥胖症和头痛都是与个人和社会有重大影响的疾病。最近的数据表明，肥胖症与头痛（一般而言）和偏头痛（特别是）以及某些继发性头痛疾病（如特发性颅内高压）都有共病关系。在本手稿中，我们首先简要回顾了肥胖症和常见原发性和继发性头痛疾病的流行病学。接下来，我们系统地回顾了评估一般人群中肥胖症与头痛之间关系的研究数据，然后评估了肥胖症与偏头痛和紧张型头痛障碍之间的关系。最后，我们简要讨论了与肥胖症相关的一种常见继发性头痛疾病（特发性颅内高压）之间关联的数据。总的来说，鉴于这种关联具有潜在的可修饰性，因此，临床医生和患者都应该意识到头痛/偏头痛-肥胖症之间的关联。肥胖症与偏头痛关联的机制假说以及超重和肥胖头痛患者的治疗注意事项在本主题的第二部分，即本文的姊妹篇中进行了讨论。
