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终身自发性运动对超老龄小鼠骨骼肌和血管生成的影响。

Effects of lifelong spontaneous exercise on skeletal muscle and angiogenesis in super-aged mice.

机构信息

Department of Physical Education, Gyeongsang National University, Jinju, Korea.

Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Korea.

出版信息

PLoS One. 2022 Aug 17;17(8):e0263457. doi: 10.1371/journal.pone.0263457. eCollection 2022.

DOI:10.1371/journal.pone.0263457
PMID:35976884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9384990/
Abstract

There has been an increasing awareness of sarcopenia, which is characterized by a concomitant decrease in skeletal muscle mass and quality due to aging. Resistance exercise is considered more effective than aerobic exercise in terms of therapeutic exercise. To confirm the effect of long-term aerobic exercise in preventing sarcopenia, we evaluated the skeletal muscle mass, quality, and angiogenic capacity of super-aged mice that had undergone lifelong spontaneous exercise (LSE) through various experiments. Our findings show that LSE could maintain skeletal muscle mass, quality, and fitness levels in super-aged mice. In addition, ex vivo experiments showed that the angiogenic capacity was maintained at a high level. However, these results were not consistent with the related changes in the expression of genes and/or proteins involved in protein synthesis or angiogenesis. Based on the results of previous studies, it seems certain that the expression at the molecular level does not represent the phenotypes of skeletal muscle and angiogenesis. This is because aging and long-term exercise are variables that can affect both protein synthesis and the expression patterns of angiogenesis-related genes and proteins. Therefore, in aging and exercise-related research, various physical fitness and angiogenesis variables and phenotypes should be analyzed. In conclusion, LSE appears to maintain the potential of angiogenesis and slow the aging process to maintain skeletal muscle mass and quality. Aerobic exercise may thus be effective for the prevention of sarcopenia.

摘要

人们对肌肉减少症的认识日益提高，其特征是由于衰老导致骨骼肌质量和功能同时下降。与有氧运动相比，抗阻运动被认为在治疗运动方面更有效。为了证实长期有氧运动预防肌肉减少症的效果，我们通过各种实验评估了终生自发性运动（LSE）的超级老年小鼠的骨骼肌质量、质量和血管生成能力。我们的研究结果表明，LSE 可以维持超级老年小鼠的骨骼肌质量、质量和健康水平。此外，离体实验表明血管生成能力保持在较高水平。然而，这些结果与参与蛋白质合成或血管生成的基因和/或蛋白质表达的相关变化不一致。基于之前的研究结果，分子水平的表达似乎并不能代表骨骼肌和血管生成的表型，这似乎是确定无疑的。这是因为衰老和长期运动是可以影响蛋白质合成和血管生成相关基因和蛋白质表达模式的变量。因此，在与衰老和运动相关的研究中，应该分析各种健康和血管生成变量以及表型。总之，LSE 似乎可以保持血管生成的潜力，减缓衰老过程，从而维持骨骼肌的质量和功能。因此，有氧运动可能对预防肌肉减少症有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ea/9384990/4fc89ead5dea/pone.0263457.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ea/9384990/2fd2c8ad45d2/pone.0263457.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ea/9384990/e48abeb15946/pone.0263457.g008.jpg
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