Rozalski A, Kotełko K
J Clin Microbiol. 1987 Jun;25(6):1094-6. doi: 10.1128/jcm.25.6.1094-1096.1987.
Twenty strains of Proteus penneri obtained from the Centers for Disease Control, Atlanta, Ga., were tested for their ability to hemolyze sheep and human erythrocytes, a property that is thought to be connected with the invasiveness and virulence of Proteus species. In the logarithmic phase of growth, P. penneri cultures are hemolytic for such erythrocytes. This ability is comparable to the hemolysis exhibited by nearly 100% of P. vulgaris and P. mirabilis strains, which is due to the production of a cell-bound hemolytic factor; is demonstrated only in broth cultures; and seems to facilitate the penetration of P. penneri and other Proteus species into the cells without cytotoxic effects. In contrast, a filterable alpha-hemolysin, which is produced transiently by a very few strains of P. mirabilis, was present in 4 of 20 P. penneri strains. This property, which is expressed at a high level over a long period, suggests a chromosomal origin. The penetration of an alpha-hemolytic P. penneri strain into Vero cells was accompanied by a drastic cytotoxic effect.
从佐治亚州亚特兰大疾病控制中心获取的20株彭氏变形杆菌菌株，检测了它们对绵羊和人红细胞的溶血能力，这种特性被认为与变形杆菌属的侵袭性和毒力有关。在对数生长期，彭氏变形杆菌培养物对这类红细胞具有溶血作用。这种能力与近100%的普通变形杆菌和奇异变形杆菌菌株所表现出的溶血作用相当，这是由于产生了一种细胞结合溶血因子；仅在肉汤培养物中表现出来；并且似乎有助于彭氏变形杆菌和其他变形杆菌属细菌侵入细胞而无细胞毒性作用。相比之下，20株彭氏变形杆菌菌株中有4株存在一种可过滤的α溶血素，这种溶血素由极少数奇异变形杆菌菌株短暂产生。这种在很长一段时间内高水平表达的特性表明其起源于染色体。一株α溶血的彭氏变形杆菌菌株侵入Vero细胞时伴随着剧烈的细胞毒性作用。
