Greendyke R M, Kanter D R
J Clin Psychopharmacol. 1987 Jun;7(3):178-82.
The relationship between chronic oral dosage with a long-acting formulation of propranolol and plasma propranolol levels 22 to 23 hours later is described in 12 adult male patients with organic brain disease. Separately, the effects on plasma levels of thioridazine plus metabolites with concomitant rising dose long-acting propranolol administration were studied in five patients. Significant dose-related increases in levels of thioridazine and metabolites were found when long-acting propranolol was given. No changes in haloperidol levels were found in three patients studied in a similar protocol.
在12名患有器质性脑疾病的成年男性患者中，描述了长效普萘洛尔的慢性口服剂量与22至23小时后血浆普萘洛尔水平之间的关系。另外，在5名患者中研究了同时给予递增剂量长效普萘洛尔对硫利达嗪及其代谢产物血浆水平的影响。给予长效普萘洛尔时，发现硫利达嗪及其代谢产物水平有显著的剂量相关增加。在采用类似方案研究的3名患者中，未发现氟哌啶醇水平有变化。
