Väisänen K, Rimón R, Räisänen P, Viukari M
Acta Psychiatr Belg. 1979 Nov-Dec;79(6):673-85.
A randomized cross-over trial was conducted in 30 restless mentally subnormal patients by increasing the dosage of haloperidol from 10 to 60 mg and of thioridazine from 100 to 600 mg daily. The effects of drug holidays and serum drug levels were also examined. Mesoridazine had 5-6 times higher serum levels than the parent compound and relatively high serum levels are achieved already with moderate doses. The observed differences between haloperidol and thioridazine treatment were surprisingly few. Serum cholesterol was higher (P < 0.05) at the end of the thioridazine administration. Drug holidays may benefit may patients.
对30名精神不安的智力发育迟缓患者进行了一项随机交叉试验，将氟哌啶醇的日剂量从10毫克增加到60毫克，硫利达嗪的日剂量从100毫克增加到600毫克。还研究了停药期和血清药物水平的影响。美索达嗪的血清水平比母体化合物高5至6倍，中等剂量就能达到相对较高的血清水平。氟哌啶醇和硫利达嗪治疗之间观察到的差异出奇地少。硫利达嗪给药结束时血清胆固醇较高（P<0.05）。停药期可能对许多患者有益。
