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基于生物信息学分析的肺腺癌中 STING 表达和甲基化的临床意义。

Clinical significance of STING expression and methylation in lung adenocarcinoma based on bioinformatics analysis.

机构信息

Department of Biochemistry, Shantou University Medical College, Shantou, People's Republic of China.

Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, People's Republic of China.

出版信息

Sci Rep. 2022 Aug 17;12(1):13951. doi: 10.1038/s41598-022-18278-6.

DOI:10.1038/s41598-022-18278-6
PMID:35978045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9385651/
Abstract

The role of stimulator of interferon genes [STING, also known as transmembrane protein 173 (TMEM173)] in various human cancers has begun to emerge. However, the clinical value of STING in lung adenocarcinoma (LUAD) remains elusive. This study aims to elucidate the clinical significance of STING expression and methylation in LUAD. Here, through analyzing data from public resources, we found that both the mRNA and protein expression of STING were reduced in lung cancer. Moreover, lower expression of STING was associated with a worse prognosis in LUAD, but not lung squamous cell carcinoma (LUSC). Of note, higher methylation of STING was found in LUAD and had the potential to distinguish LUAD tissues from adjacent non-tumor lung tissues and correlated with unfavorable outcomes. Furthermore, the methylation of STING could serve as an independent prognostic indicator for both the overall survival (OS) and disease-free survival (DFS) of LUAD patients. Additionally, the constructed nomogram exhibited a favorable predictive accuracy in predicting the probability of 1- and 2-year OS. Our findings suggest that the mRNA expression, and especially the DNA methylation of STING, have the potential to be prognostic indicators for LUAD patients.

摘要

干扰素基因刺激物（STING，也称为跨膜蛋白 173（TMEM173））在各种人类癌症中的作用开始显现。然而，STING 在肺腺癌（LUAD）中的临床价值仍不清楚。本研究旨在阐明 STING 表达和甲基化在 LUAD 中的临床意义。在这里，通过分析公共资源的数据，我们发现 STING 的 mRNA 和蛋白表达在肺癌中均降低。此外，STING 表达水平较低与 LUAD 的预后较差相关，但与肺鳞状细胞癌（LUSC）无关。值得注意的是，在 LUAD 中发现了更高的 STING 甲基化，并且有可能将 LUAD 组织与相邻的非肿瘤肺组织区分开来，并与不良结果相关。此外，STING 的甲基化可作为 LUAD 患者总生存期（OS）和无病生存期（DFS）的独立预后指标。此外，构建的列线图在预测 1 年和 2 年 OS 概率方面表现出良好的预测准确性。我们的研究结果表明，STING 的 mRNA 表达，尤其是 DNA 甲基化，有可能成为 LUAD 患者的预后指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/c6eae51992ce/41598_2022_18278_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/cd573f70043d/41598_2022_18278_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/b6acc02f18a5/41598_2022_18278_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/46389f00f509/41598_2022_18278_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/aefb29e278b1/41598_2022_18278_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/06452795259e/41598_2022_18278_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/c6eae51992ce/41598_2022_18278_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/cd573f70043d/41598_2022_18278_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/b6acc02f18a5/41598_2022_18278_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/46389f00f509/41598_2022_18278_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/aefb29e278b1/41598_2022_18278_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/06452795259e/41598_2022_18278_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b58c/9385651/c6eae51992ce/41598_2022_18278_Fig6_HTML.jpg

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Sci Rep. 2025-7-28

[2]
The role of type I interferon signaling in myeloid anti-tumor immunity.

Front Immunol. 2025-3-3

[3]
Differential Response to Local Stimulator of Interferon Genes Agonist Administration in Tumors with Various Stimulator of Interferon Genes Statuses.

Cancers (Basel). 2025-1-8

[4]
The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy.

Int J Nanomedicine. 2024

[5]
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J Pathol Transl Med. 2024-11

[6]
Epigenome-wide association study of prostate cancer in African American men identified differentially methylated genes.

Cancer Med. 2024-8

[7]
Prognostic and immunological significance of metastasis-associated protein 3 in patients with thymic epithelial tumors.

Discov Oncol. 2024-6-9

[8]
Role of STING in the treatment of non-small cell lung cancer.

Cell Commun Signal. 2024-4-2

[9]
Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy.

Mater Today Bio. 2024-3-11

[10]
The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications.

Clin Epigenetics. 2024-2-8

本文引用的文献

[1]
Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells.

Thorac Cancer. 2022-5

[2]
LncRNA PCAT1 activates SOX2 and suppresses radioimmune responses via regulating cGAS/STING signalling in non-small cell lung cancer.

Clin Transl Med. 2022-4

[3]
Loss of STING expression is prognostic in non-small cell lung cancer.

J Surg Oncol. 2022-5

[4]
Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell lung cancer.

Int J Biol Sci. 2022

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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.

Cell. 2022-1-6

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DNA methylation in lung cancer patients: Opening a "window of life" under precision medicine.

Biomed Pharmacother. 2021-12

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Trends Genet. 2021-11

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MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING.

Cancer Discov. 2021-11

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RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma.

Cell Biosci. 2021-4-15

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cGAS-STING pathway expression as a prognostic tool in NSCLC.

Transl Lung Cancer Res. 2021-1

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