School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC Ophthalmol. 2022 Aug 17;22(1):346. doi: 10.1186/s12886-022-02571-z.
Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM). Systemic inflammation is intimately associated with DR. The neutrophil-to-lymphocyte ratio (NLR) index is a relatively new indicator of inflammation.
This cross-sectional study was carried out among adults with DM based on the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2016. NLR was presented as absolute neutrophil counts/ absolute lymphocyte counts. The relationship of NLR levels to DR was analyzed using multivariable logistic regression.
There were 2772 eligible subjects extracted from the NHANES. In the multivariate analysis, NLR was related to the risk of DR after adjustment for potential confounders. The association between NLR levels and DR was nonlinear, with an inflection point of 4.778. Compared with the baseline values, NLR was not statistically significant on the right side of the inflection point (1.000, 0.914 to 1.094, 0.9974) but was positively associated with DR on the left side (1.236, 1.132 to 1.349, < 0.0001).
NLR reflects systemic inflammation that may increase the risk of DR. NLR positively correlates with DR when its value is less than 4.778.
糖尿病视网膜病变（DR）是糖尿病（DM）的常见并发症。全身炎症与 DR 密切相关。中性粒细胞与淋巴细胞比值（NLR）指数是一种相对较新的炎症指标。
本横断面研究基于 2009 年至 2016 年国家健康和营养检查调查（NHANES），在成年 DM 患者中进行。NLR 表示绝对中性粒细胞计数/绝对淋巴细胞计数。使用多变量逻辑回归分析 NLR 水平与 DR 的关系。
从 NHANES 中提取了 2772 名合格受试者。在多变量分析中，NLR 与调整潜在混杂因素后的 DR 风险相关。NLR 水平与 DR 之间的关系是非线性的，拐点为 4.778。与基线值相比，拐点右侧 NLR 无统计学意义（1.000，0.914 至 1.094，0.9974），但左侧 NLR 与 DR 呈正相关（1.236，1.132 至 1.349，<0.0001）。
NLR 反映全身炎症，可能增加 DR 的风险。当 NLR 值小于 4.778 时，其与 DR 呈正相关。
