中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值与卒中后抑郁的相关性：系统评价和荟萃分析。
Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Poststroke Depression: A Systematic Review and Meta-Analysis.
机构信息
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Dis Markers. 2022 Aug 8;2022:5911408. doi: 10.1155/2022/5911408. eCollection 2022.
OBJECTIVES
Evidence shows that stroke-induced inflammatory responses play an essential role in the development of poststroke depression (PSD). The goal of this systematic review and meta-analysis was to critically evaluate the literature regarding the use of the neutrophil to lymphocyte ratio (NLR) as a reliable means to detect early PSD development, to help clinicians institute early interventions and improve outcomes.
METHODS
Electronic databases, including Web of Science, PubMed, Google Scholar, and Scopus, were searched, and eight studies were included. We assessed the certainty of the associations with GRADE methods.
RESULTS
We found that patients with PSD had higher NLR than the stroke patients with no depression (SMD = 0.51; CI 95% = 0.29-0.73, < 0.001). Also, we found a significantly higher PLR in the patients with PSD when compared to the stroke patients with no depression (SMD = 0.66; CI 95% = 0.19-1.13, < 0.001).
CONCLUSION
These findings indicated that NLR and PLR could be considered inexpensive biomarkers for the prediction of PSD.
目的
有证据表明，卒中引起的炎症反应在卒中后抑郁（PSD）的发展中起着至关重要的作用。本系统评价和荟萃分析的目的是批判性地评估有关中性粒细胞与淋巴细胞比值（NLR）作为检测早期 PSD 发展的可靠手段的文献，以帮助临床医生进行早期干预并改善预后。
方法
我们检索了电子数据库，包括 Web of Science、PubMed、Google Scholar 和 Scopus，并纳入了 8 项研究。我们使用 GRADE 方法评估了关联的确定性。
结果
我们发现 PSD 患者的 NLR 高于无抑郁的卒中患者（SMD=0.51；95%CI=0.29-0.73，<0.001）。此外，我们发现 PSD 患者的血小板与淋巴细胞比值（PLR）显著高于无抑郁的卒中患者（SMD=0.66；95%CI=0.19-1.13，<0.001）。
结论
这些发现表明，NLR 和 PLR 可以被视为预测 PSD 的廉价生物标志物。
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