一名患有克兰费尔特综合征合并抗磷脂综合征患者的免疫吸附治疗：病例报告。
Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report.
作者信息
Song You, Xiao Yong-Zhen, Wang Cheng, Du Rong
机构信息
Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
出版信息
World J Clin Cases. 2022 Jul 6;10(19):6580-6586. doi: 10.12998/wjcc.v10.i19.6580.
BACKGROUND
Klinefelter syndrome (KS) is a genetic disease of male sex chromosome malformations that affects sperm production and reduces testosterone production. It has been reported that there is currently more than 10 cases of KS combined with antiphospholipid syndrome.
CASE SUMMARY
Here, we describe a 31-year-old male patient with chromosome 47, XXY type, who suffered deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VIII. After treatment with immunoadsorption therapy, glucocorticoids, cyclophosphamide, intravenous immunoglobulin and anticoagulant therapy, the patient showed dramatic symptomatic improvement. During the follow-up, the patient did not develop any new thrombotic events.
CONCLUSION
Immunoadsorption combined with glucocorticoid and cyclophosphamide shock comprehensive treatment has achieved significant results for patients with KS combined with antiphospholipid syndrome.
背景
克兰费尔特综合征（KS）是一种男性性染色体畸形的遗传性疾病，会影响精子生成并降低睾酮分泌。据报道，目前已有超过10例KS合并抗磷脂综合征的病例。
病例摘要
在此，我们描述一名31岁的男性患者，染色体核型为47, XXY，患有下肢深静脉血栓形成，并伴有抗磷脂抗体、狼疮抗凝物及凝血因子Ⅷ异常。经免疫吸附治疗、糖皮质激素、环磷酰胺、静脉注射免疫球蛋白及抗凝治疗后，患者症状显著改善。随访期间，患者未出现任何新的血栓形成事件。
结论
免疫吸附联合糖皮质激素及环磷酰胺冲击综合治疗对KS合并抗磷脂综合征患者取得了显著疗效。
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