Campbell W A, Price W H
Clin Genet. 1981 Apr;19(4):275-80. doi: 10.1111/j.1399-0004.1981.tb00709.x.
In a series of 412 patients with Klinefelter's syndrome observed over periods ranging from 1 to 20 years, the frequency of hypostatic ulceration, deep vein thrombosis and pulmonary embolism was found to be raised. The prevalence of past or present hypostatic ulceration was 6%, which is 20-50 times higher than in the general population. The incidence of deep vein thrombosis in subjects aged between 30 and 70 years was 22.8 cases per 10,000 patient-years at risk. In community studies the incidence of this condition is around 4 new cases per 10,000 men per year. The frequency of pulmonary embolism was 16 cases per 10,000 patient-years at risk, compared with an expected figure of 0.9 to 3 cases per 10,000 men per year.
在对412例患有克兰费尔特综合征的患者进行的一系列观察中，观察期从1年至20年不等，发现坠积性溃疡、深静脉血栓形成和肺栓塞的发生率有所升高。既往或目前坠积性溃疡的患病率为6%，这比普通人群高出20至50倍。年龄在30至70岁之间的受试者深静脉血栓形成的发生率为每10000患者-年有22.8例。在社区研究中，这种疾病的发病率约为每年每10000名男性中有4例新发病例。肺栓塞的发生率为每10000患者-年有16例，而预期数字为每年每10000名男性中有0.9至3例。
