同一肺叶内鳞状细胞癌与肺朗格汉斯细胞组织细胞增多症的两种吸烟相关病变：病例报告
Two smoking-related lesions in the same pulmonary lobe of squamous cell carcinoma and pulmonary Langerhans cell histiocytosis: A case report.
作者信息
Gencer Aysegul, Ozcibik Gizem, Karakas Fatma Gulsum, Sarbay Ismail, Batur Sebnem, Borekci Sermin, Turna Akif
机构信息
Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty Campus, Istanbul 34098, Turkey.
Department of Thoracic Surgery, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul 34098, Turkey.
出版信息
World J Clin Cases. 2022 Jul 6;10(19):6722-6727. doi: 10.12998/wjcc.v10.i19.6722.
BACKGROUND
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung.
CASE SUMMARY
A 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH.
CONCLUSION
Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
背景
肺朗格汉斯细胞组织细胞增多症（PLCH）是一种罕见的囊性肺部疾病，通常影响年轻成年人。据预测，PLCH是一种与肺内髓样树突状细胞功能障碍相关的肺肿瘤前体。
病例摘要
一名70岁男性患者出现慢性咳嗽和咳痰症状。他有5年的症状史，并描述在过去3年中运动时气短。他有60包/年的吸烟史。胸部计算机断层扫描显示右肺下叶上段有一个11毫米的结节，右肺下叶后基底段有一个7毫米的结节。通过右胸腔镜手术切除了这两个结节。病理评估显示为鳞状细胞癌和PLCH。
结论
鳞状细胞癌与PLCH并存提示PLCH与肺癌之间可能存在关联。
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