2008年至2017年佛山市无偿献血者梅毒感染情况分析

[Trend of Syphilis Infection among Voluntary Blood Donors in Foshan City from 2008 to 2017].

作者信息

Lin Jun-Tian, Wu Wei-Jian, Yang Fu-Yan, Yu Yu-Ting, Li Yan-Hua, Yu Jin-Lin

机构信息

Foshan Central Blood Station, Foshan 528000, Guangdong Province, China,E-mail:

Foshan Central Blood Station, Foshan 528000, Guangdong Province, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Apr;28(2):641-645. doi: 10.19746/j.cnki.issn.1009-2137.2020.02.047.

DOI:10.19746/j.cnki.issn.1009-2137.2020.02.047

PMID:32319409

Abstract

OBJECTIVE

To investigate the prevalence of syphilis infection in voluntary blood donors in Foshan City, so as to provide reference for improving the infusion blood safety strategy of city.

METHODS

A total of 657 382 voluntary blood donors in Foshan City from January 2008 to December 2017 were selected. The blood samples were tested for treponema pallidum. The prevalence trends, the detection rate of treponema pallidum infection and epidemiological data were statistically analyzed. Enzyme-linked immunosorbent assay (ELISA) was performed for antibody screening in blood samples. The two-hole retest was then performed for the samples which were positive in initial test, meanwhile, they were also confirmed by the treponema hemagglutination blood coagulation test (TPHA).

RESULTS

First, the annual infection rate of treponema pallidum in Foshan City from January 2008 to December 2017 was 0.43%, 0.40%, 0.41%, 0.43%, 0.50%, 0.32%, 0.36%, 0.32%, 0.37% and 0.32%, respectively. A total of 2502 cases of treponema pallidum infection were detected, the overall infection rate was 0.38%, and the infection rate decreased year by year (x=23.826, P＜0.05). Second, among the 657 382 samples of voluntary blood donors, 2 502 were showed the positive treponema pallidum antibody (0.38%). In 2015-2017, 791 donors were showed positive treponema pallidum antibody, 676 case out of which were confirmed positive, 0.34% with the positive coincidence rate of 85.46%. Third, this group of 676 syphilis infection cases were male-dominated (0.35%, 577/164 484). The age distribution was 18-53 years old, and the average age was 32 years, among which 35-44 years old accounted for 0.33% (138/41 858). The education level of in donors with treponema pallidom positive mainly ranked at low or lower levels under janior college (0.32%, 571/180 917). The occupation is mainly outside work and company staff (0.39%, 452/115 101). The marital status is mainly unmarried (0.29%, 377/130 905). The place of origin is mainly non-local (0.29%,570/198 063).

CONCLUSION

The positive rate of treponema pallidum shows a downward trend in 2008-2017. Among the individuals with comfirmed TP antibody positive in 2015-2017, the non-local, unmarried and low educated males are main population, moreover more than half of them are migrant worker or company employeers.

摘要

目的

调查佛山市无偿献血者梅毒感染情况，为完善该市输血安全策略提供参考。

方法

选取2008年1月至2017年12月佛山市657382名无偿献血者，检测血液样本梅毒螺旋体，对梅毒感染流行趋势、梅毒螺旋体感染检测率及流行病学资料进行统计分析。采用酶联免疫吸附试验（ELISA）对血液样本进行抗体筛查，初筛阳性样本进行双孔复检，同时采用梅毒螺旋体血凝试验（TPHA）进行确认。

结果

一是2008年1月至2017年12月佛山市梅毒螺旋体年感染率分别为0.43%、0.40%、0.41%、0.43%、0.50%、0.32%、0.36%、0.32%、0.37%、0.32%。共检测出梅毒螺旋体感染2502例，总感染率为0.38%，且感染率逐年下降（χ²=23.826，P＜0.05）。二是657382份无偿献血者样本中，梅毒螺旋体抗体阳性2502例（0.38%）。2015 - 2017年，791名献血者梅毒螺旋体抗体阳性，其中676例确诊阳性，阳性符合率为85.46%，感染率为0.34%。三是这676例梅毒感染病例以男性为主（0.35%，577/164484），年龄分布为18 - 53岁，平均年龄32岁，其中35 - 44岁占0.33%（138/41858）。梅毒螺旋体阳性献血者文化程度主要为大专及以下低学历水平（0.32%，571/180917）。职业主要为外出务工及公司职员（0.39%，452/115101）。婚姻状况主要为未婚（0.29%，377/130905）。籍贯主要为非本地（0.29%，570/198063）。