Xu Chenlu, Yu Dan, Zhu Huiyong
Department of Stomatology, the First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou Zhejiang, 310003, P. R. China.
Medical College of Zhejiang University, Hangzhou Zhejiang, 310030, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022 Aug 15;36(8):1041-1046. doi: 10.7507/1002-1892.202201028.
To summary the regulatory effect of mechanical stimulation on macrophage polarization in wound healing, and explore the application prospect of mechanical stimulation in tissue engineering.
The related domestic and foreign literature in recent years was extensive reviewed, and the different phenotypes of macrophages and their roles in wound healing, the effect of mechanical stimulation on macrophage polarization and its application in tissue engineering were analyzed.
Macrophages have functional diversity, with two phenotypes: pro-inflammatory (M1 type) and anti-inflammatory (M2 type), and the cells exhibit different activation phenotypes and play corresponding functions under different stimuli. The mechanical force of different types, sizes, and amplitudes can directly or indirectly guide macrophages to transform into different phenotypes, and then affect tissue repair. This feature can be used in tissue engineering to selectively regulate macrophage polarization.
Mechanical stimulation plays an vital role in regulating macrophage polarization, but its specific role and mechanism remain ambiguous and need to be further explored.
总结机械刺激在伤口愈合中对巨噬细胞极化的调节作用，并探讨机械刺激在组织工程中的应用前景。
广泛回顾近年来国内外相关文献，分析巨噬细胞的不同表型及其在伤口愈合中的作用、机械刺激对巨噬细胞极化的影响及其在组织工程中的应用。
巨噬细胞具有功能多样性，有促炎（M1型）和抗炎（M2型）两种表型，细胞在不同刺激下表现出不同的激活表型并发挥相应功能。不同类型、大小和幅度的机械力可直接或间接引导巨噬细胞转变为不同表型，进而影响组织修复。这一特性可用于组织工程中选择性调节巨噬细胞极化。
机械刺激在调节巨噬细胞极化中起重要作用，但其具体作用和机制仍不明确，有待进一步探索。
