将离子载体 PBT2 再利用治疗耐多药淋病奈瑟菌感染。
Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections.
机构信息
Institute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast Campus, Queensland, Australia.
The Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University, Ohio, USA.
出版信息
Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0231821. doi: 10.1128/aac.02318-21. Epub 2022 Aug 18.
Abstract
Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.
摘要
耐多药（MDR）淋病奈瑟菌是当前的公共卫生威胁。迫切需要新的治疗方法。PBT2 是一种离子载体，可破坏金属动态平衡。研究表明，PBT2 与锌联合使用可逆转几种细菌病原体对抗生素的耐药性。本文显示，脑膜炎奈瑟球菌和耐多药淋病奈瑟菌均对 PBT2 的单独杀伤作用敏感。因此，PBT2 是治疗耐多药淋病奈瑟菌感染的候选药物。
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