Ursu Ramona Gabriela, Luchian Ionut, Damian Costin, Porumb-Andrese Elena, Cobzaru Roxana Gabriela, Nichitean Giorgio, Ripa Carmen, Costin Diana, Sandu Darius, Andrioaie Ioana-Maria, Iancu Luminita Smaranda
Department of Preventive Medicine and Interdisciplinarity (IX)-Microbiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Periodontology, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Microorganisms. 2022 Dec 1;10(12):2388. doi: 10.3390/microorganisms10122388.
is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as sterility or ectopic pregnancies. One important issue about is its increasing resistance to antibiotics. This paper summarized the newest molecular antimicrobial resistance (AMR) detection assays for connected with the latest therapeutic antimicrobials and gonococcal vaccine candidates. The assays used to detect AMR varied from the classical minimal inhibitory concentration (MIC) detection to whole-genome sequencing. New drugs against multi drug resistant (MDR) have been proposed and were evaluated in vivo and in vitro as being efficient in decreasing the burden. In addition, anti- vaccine candidates are being researched, which have been assessed by multiple techniques. With the efforts of many researchers who are studying the detection of antimicrobial resistance in this bacterium and identifying new drugs and new vaccine candidates against it, there is hope in reducing the gonorrhea burden worldwide.
是性传播疾病（STD）最常见的病原体之一。女性未经治疗的无症状淋病感染可导致感染在性活跃人群中传播，并可能导致诸如不育或异位妊娠等晚期后果。关于它的一个重要问题是其对抗生素的耐药性不断增加。本文总结了与最新治疗性抗菌药物和淋病疫苗候选物相关的淋病最新分子抗菌药物耐药性（AMR）检测方法。用于检测AMR的方法从经典的最低抑菌浓度（MIC）检测到全基因组测序不等。已提出针对多重耐药（MDR）淋病的新药，并在体内和体外进行了评估，结果表明它们在减轻淋病负担方面有效。此外，正在研究抗淋病疫苗候选物，这些候选物已通过多种技术进行评估。通过许多研究人员在研究该细菌抗菌药物耐药性检测以及鉴定针对它的新药和新疫苗候选物方面的努力，有望减轻全球淋病负担。
