Clay J R
J Membr Biol. 1978 Sep 19;42(3):215-27. doi: 10.1007/BF01870359.
The theoretical power density spectrum S(f) of ion current noise is calculated from several models of the sodium channel gating mechanism in nerve membrane. Sodium ion noise experimental data from the frog node of Ranvier [Conti, F., et al. (1976), J. Physiol. (London) 262:699] is used as a test of the theoretical results. The motivation for recent modeling has been evidence for a coupling between sodium activation and inactivation from voltage clamp data. The two processes are independent of one another in the Hodgkin and Huxley (HH) model [Hodgkin A.L., Huxley, A.F. (1952), J. Physiol. (London) 117:500]. The noise data is consistent with HH, as noted by Conti et al. (1976). The theoretical results given here appear to indicate that only one case of coupling models is also consistent with the noise data.
离子电流噪声的理论功率密度谱S(f)是根据神经膜中钠通道门控机制的几种模型计算得出的。来自青蛙郎飞结的钠离子噪声实验数据[Conti, F., 等人 (1976), 《生理学杂志》(伦敦) 262:699]被用作对理论结果的检验。近期建模的动机是电压钳数据表明钠激活与失活之间存在耦合。在霍奇金和赫胥黎（HH）模型[霍奇金A.L., 赫胥黎, A.F. (1952), 《生理学杂志》(伦敦) 117:500]中，这两个过程相互独立。如Conti等人（1976）所指出的，噪声数据与HH模型一致。这里给出的理论结果似乎表明，只有一种耦合模型情况也与噪声数据一致。
