关于离子跨神经膜运输的理论。IV. K+通道开闭动力学产生的噪声
On the theory of ion transport across the nerve membrane. IV. Noise from the open-close kinetics of K + channels.
作者信息
Hill T L, Chen Y D
出版信息
Biophys J. 1972 Aug;12(8):948-59. doi: 10.1016/S0006-3495(72)86136-8.
Abstract
The theoretical power density spectrum G(f) of fluctuations in the steady-state squid axon K(+) current in the 10(3) Hz region has been derived assuming that these are fluctuations in the number of open K(+) channels in the Hodgkin-Huxley (HH) model. Various modifications of the HH model were also studied. The results were negative in all cases when compared with experiment. This confirms the generally held view that the observed G(f) approximately 1/f is associated primarily with K(+) current through open K(+) channels and not with the open-close kinetics of these channels.
摘要
假设稳态鱿鱼轴突钾离子电流在10³Hz区域内的波动是霍奇金-赫胥黎（HH）模型中开放钾离子通道数量的波动，推导出了其理论功率密度谱G(f)。还研究了HH模型的各种修正。与实验相比，所有情况下结果均为阴性。这证实了普遍持有的观点，即观察到的G(f)约为1/f主要与通过开放钾离子通道的钾离子电流相关，而不是与这些通道的开闭动力学相关。
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