锌和地塞米松对无毛小鼠皮肤中金属硫蛋白的特异性诱导作用。
Specific induction of metallothionein in hairless mouse skin by zinc and dexamethasone.
作者信息
Mullin C H, Frings G, Abel J, Kind P P, Goerz G
出版信息
J Invest Dermatol. 1987 Aug;89(2):164-6. doi: 10.1111/1523-1747.ep12470553.
PMID:3598209
Abstract
The stimulation of metallothionein (MT) synthesis in mouse skin after i.p. treatments with various doses of dexamethasone or zinc was demonstrated. Specific MT mRNA induction was determined by Northern analysis. Zinc was a more efficient inducer than dexamethasone. The maximal MT accumulation occurs after i.p. injections of 50-100 mg dexamethasone/kg body weight. The possible role of MT in the skin is briefly discussed.
摘要
经腹腔注射不同剂量地塞米松或锌后，小鼠皮肤中金属硫蛋白（MT）合成受到刺激得以证实。通过Northern分析确定了特异性MT mRNA的诱导情况。锌是比地塞米松更有效的诱导剂。腹腔注射50 - 100毫克地塞米松/千克体重后，MT积累达到最大值。文中简要讨论了MT在皮肤中的可能作用。
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