Quinones S R, Cousins R J
Biochem J. 1984 May 1;219(3):959-63. doi: 10.1042/bj2190959.
The induction of liver metallothionein by dexamethasone in adrenalectomized rats was augmented by zinc administration. Metallothionein synthesis was increased in an additive manner with both zinc and dexamethasone compared with either treatment alone. Translational activity of polyribosomal metallothionein mRNA was also greater in zinc + dexamethasone-treated rats. Northern-blot analyses showed that dexamethasone increased these mRNA contents to a greater extent at the lower zinc dose, suggesting that the induction may be maximal at the higher zinc dose when combined with dexamethasone.
在肾上腺切除的大鼠中，地塞米松对肝脏金属硫蛋白的诱导作用通过给予锌而增强。与单独使用任何一种处理相比，锌和地塞米松联合使用时金属硫蛋白的合成以累加方式增加。在锌+地塞米松处理的大鼠中，多核糖体金属硫蛋白mRNA的翻译活性也更高。Northern印迹分析表明，在较低锌剂量下，地塞米松能更大程度地增加这些mRNA的含量，这表明当与地塞米松联合使用时，在较高锌剂量下诱导作用可能达到最大。
