2019冠状病毒病对人类生殖有影响吗？
Can Coronavirus Disease 2019 Effect on Human Reproduction?
作者信息
Abdolrazaghnejad Ali, Miraj Sepideh
机构信息
Department of Emergency Medicine, Khatam-Al-Anbia Hospital, Clinical Immunology Research Center at Zahedan University of Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Obstetrics and Gynecology, Nekouei-Hedayati-Forghani Hospital, Qom University of Medical Sciences, Qom, Iran.
出版信息
Adv Biomed Res. 2022 Jun 29;11:55. doi: 10.4103/abr.abr_236_21. eCollection 2022.
Since the main role in the pathogenesis of the coronavirus is attributed to the angiotensin-converting enzyme (ACE) receptor, it could possibly be a hypothesis in the differential sex-based pathogenesis of the coronavirus. The virus inserts its genetic material into the cell through its ACE2 receptors and replicates it by intracellular proteins. ACE2 receptors are highly expressed in cell membranes of various tissues in the body, including cardiovascular, gastrointestinal, renal, macrophage cells, and especially on the surface of type 2 pneumocytes in the lungs, ovaries, uterus, vagina, placenta, and testes. Therefore, cells having a higher expression of the ACE2 may be a specific target for coronavirus binding and infectivity. Due to the increase of infections in males, concerns have been appeared about the potential impact of coronavirus disease 2019 (COVID-19) on their fertility and reproductive organs. Thus, it is necessary to investigate if COVID-19 disturbs female and male fertility, so this review aimed to study the comprehensive evidences on the association of COVID-19 with human reproduction.
由于冠状病毒发病机制的主要作用归因于血管紧张素转换酶（ACE）受体，这可能是冠状病毒基于性别的差异发病机制中的一个假设。病毒通过其ACE2受体将遗传物质插入细胞，并通过细胞内蛋白质进行复制。ACE2受体在身体各种组织的细胞膜中高度表达，包括心血管、胃肠道、肾脏、巨噬细胞，尤其是在肺、卵巢、子宫、阴道、胎盘和睾丸中的II型肺细胞表面。因此，ACE2表达较高的细胞可能是冠状病毒结合和感染的特定靶点。由于男性感染人数增加，人们开始关注2019冠状病毒病（COVID-19）对其生育能力和生殖器官的潜在影响。因此，有必要研究COVID-19是否会干扰女性和男性的生育能力，所以本综述旨在研究关于COVID-19与人类生殖关联的综合证据。
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