• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

分析 COVID-19 育龄妇女的性激素和月经情况。

Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age.

机构信息

Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, China.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, China.

出版信息

Reprod Biomed Online. 2021 Jan;42(1):260-267. doi: 10.1016/j.rbmo.2020.09.020. Epub 2020 Sep 29.

DOI:10.1016/j.rbmo.2020.09.020
PMID:33288478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7522626/
Abstract

RESEARCH QUESTION

Does SARS-CoV-2 infection have an effect on ovarian reserve, sex hormones and menstruation of women of child-bearing age?

DESIGN

This is a retrospective, cross-sectional study in which clinical and laboratory data from 237 women of child-bearing age diagnosed with COVID-19 were retrospectively reviewed. Menstrual data from 177 patients were analysed. Blood samples from the early follicular phase were tested for sex hormones and anti-Müllerian hormone (AMH).

RESULTS

Among 237 patients with confirmed COVID-19, severely ill patients had more comorbidities than mildly ill patients (34% versus 8%), particularly for patients with diabetes, hepatic disease and malignant tumours. Of 177 patients with menstrual records, 45 (25%) patients presented with menstrual volume changes, and 50 (28%) patients had menstrual cycle changes, mainly a decreased volume (20%) and a prolonged cycle (19%). The average sex hormone and AMH concentrations of women of child-bearing age with COVID-19 were not different from those of age-matched controls.

CONCLUSIONS

Average sex hormone concentrations and ovarian reserve did not change significantly in COVID-19 women of child-bearing age. Nearly one-fifth of patients exhibited a menstrual volume decrease or cycle prolongation. The menstruation changes of these patients might be the consequence of transient sex hormone changes caused by suppression of ovarian function that quickly resume after recovery.

摘要

研究问题

SARS-CoV-2 感染是否会影响育龄妇女的卵巢储备、性激素和月经？

设计

这是一项回顾性、横断面研究，回顾分析了 237 例确诊 COVID-19 的育龄妇女的临床和实验室数据。对 177 例患者的月经数据进行了分析。检测了早期卵泡期的血液样本中的性激素和抗苗勒管激素（AMH）。

结果

在 237 例确诊 COVID-19 的患者中，重症患者比轻症患者有更多的合并症（34%比 8%），特别是合并糖尿病、肝病和恶性肿瘤的患者。在有月经记录的 177 例患者中，45 例（25%）患者出现月经量改变，50 例（28%）患者出现月经周期改变，主要是月经量减少（20%）和周期延长（19%）。COVID-19 育龄妇女的平均性激素和 AMH 浓度与年龄匹配的对照组无差异。

结论

COVID-19 育龄妇女的平均性激素浓度和卵巢储备没有明显变化。近五分之一的患者出现月经量减少或周期延长。这些患者的月经变化可能是卵巢功能抑制导致的短暂性激素变化的结果，在恢复后很快恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/ce69e505a83e/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/fe61b4541df7/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/678e2d5ed90e/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/c59211d7c456/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/ce69e505a83e/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/fe61b4541df7/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/678e2d5ed90e/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/c59211d7c456/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35d5/7522626/ce69e505a83e/gr4_lrg.jpg

相似文献

1
Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age.分析 COVID-19 育龄妇女的性激素和月经情况。
Reprod Biomed Online. 2021 Jan;42(1):260-267. doi: 10.1016/j.rbmo.2020.09.020. Epub 2020 Sep 29.
2
Antimüllerian hormone, antral follicle count and ovarian volume predict menstrual cycle length in healthy women.抗苗勒管激素、窦卵泡计数和卵巢体积可预测健康女性的月经周期长度。
Clin Endocrinol (Oxf). 2016 Jun;84(6):870-7. doi: 10.1111/cen.12984. Epub 2015 Dec 24.
3
Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation.抗苗勒管激素作为接受卵巢组织冷冻保存的年轻癌症女性的卵巢储备标志物。
Future Oncol. 2014 Jun;10(8):1343-51. doi: 10.2217/fon.14.76.
4
COVID-19 disease does not cause ovarian injury in women of reproductive age: an observational before-and-after COVID-19 study.COVID-19 疾病不会导致育龄期女性的卵巢损伤：一项 COVID-19 前后的观察性研究。
Reprod Biomed Online. 2022 Jul;45(1):153-158. doi: 10.1016/j.rbmo.2022.03.002. Epub 2022 Mar 5.
5
Does an association exist between menstrual cycle length within the normal range and ovarian reserve biomarkers during the reproductive years? A systematic review and meta-analysis.在生殖年龄阶段，正常范围内的月经周期长度与卵巢储备生物标志物之间是否存在关联？一项系统评价与荟萃分析。
Hum Reprod Update. 2020 Nov 1;26(6):904-928. doi: 10.1093/humupd/dmaa013.
6
The association of the severity of Omicron with menstrual and premenstrual syndrome among reproductive age women in China: a cross-sectional study.奥密克戎严重程度与中国育龄期女性月经及经前期综合征的关联性：一项横断面研究。
Afr J Reprod Health. 2024 Jun 30;28(6):55-65. doi: 10.29063/ajrh2024/v28i6.6.
7
Antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) are the predictors of natural fecundability have similar trends irrespective of fertility status and menstrual characteristics among fertile and infertile women below the age of 40 years.窦卵泡计数（AFC）和血清抗苗勒管激素（AMH）是自然生育能力的预测指标，无论在 40 岁以下的生育和不孕女性中，其与生育状态和月经特征的相关性趋势相似。
Reprod Biol Endocrinol. 2019 Feb 11;17(1):20. doi: 10.1186/s12958-019-0464-0.
8
Protective effect of goserelin on ovarian reserve during (neo)adjuvant chemotherapy in young breast cancer patients: a prospective cohort study in China.戈舍瑞林对中国年轻乳腺癌患者新辅助化疗期间卵巢储备功能的保护作用：一项前瞻性队列研究。
Hum Reprod. 2021 Mar 18;36(4):976-986. doi: 10.1093/humrep/deaa349.
9
Ovarian reserve assessment in users of oral contraception seeking fertility advice on their reproductive lifespan.口服避孕药使用者的卵巢储备评估，以寻求对其生殖寿命的生育建议。
Hum Reprod. 2015 Oct;30(10):2364-75. doi: 10.1093/humrep/dev197. Epub 2015 Aug 25.
10
Role of anti-Müllerian hormone and testosterone in follicular growth: a cross-sectional study.抗苗勒管激素和睾酮在卵泡生长中的作用：一项横断面研究。
BMC Endocr Disord. 2020 Jul 8;20(1):101. doi: 10.1186/s12902-020-00569-6.

引用本文的文献

1
The potential bidirectional relationship between long COVID and menstruation.长期新冠与月经之间潜在的双向关系。
Nat Commun. 2025 Sep 16;16(1):8187. doi: 10.1038/s41467-025-62965-7.
2
Impact of COVID-19 on live birth and perinatal outcomes following subsequent frozen-thawed embryo transfer.新型冠状病毒肺炎对后续冻融胚胎移植后的活产及围产期结局的影响
J Assist Reprod Genet. 2025 Aug 15. doi: 10.1007/s10815-025-03573-8.
3
The impact of COVID-19 infection on ART outcomes: a multicenter retrospective cohort study.2019冠状病毒病感染对抗逆转录病毒治疗结局的影响：一项多中心回顾性队列研究。

本文引用的文献

1
Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response.新型冠状病毒肺炎患者的心血管并发症：病毒毒性和宿主免疫反应的后果。
Curr Cardiol Rep. 2020 Apr 21;22(5):32. doi: 10.1007/s11886-020-01292-3.
2
Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection.2019-nCoV 感染后，小肠肠细胞中特定的 ACE2 表达可能导致胃肠道症状和损伤。
Int J Infect Dis. 2020 Jul;96:19-24. doi: 10.1016/j.ijid.2020.04.027. Epub 2020 Apr 18.
3
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.
J Ovarian Res. 2025 Jul 18;18(1):156. doi: 10.1186/s13048-025-01749-5.
4
Deep learning analysis of long COVID and vaccine impact in low- and middle-income countries (LMICs): development of a risk calculator in a multicentric study.低收入和中等收入国家（LMICs）中长新冠及疫苗影响的深度学习分析：一项多中心研究中风险计算器的开发
Front Public Health. 2025 Jun 26;13:1416273. doi: 10.3389/fpubh.2025.1416273. eCollection 2025.
5
Structural and Hormonal Changes in Reproductive-Age Women Post-COVID-19: A Cross-Sectional Ultrasound and Biochemical Study.新冠疫情后育龄女性的结构和激素变化：一项横断面超声与生化研究
Diagnostics (Basel). 2025 Jun 17;15(12):1536. doi: 10.3390/diagnostics15121536.
6
The Clinical and Metabolic Profiles in Menstrual Changes Among Reproductive-Aged Women Post-COVID-19.新冠疫情后育龄女性月经变化的临床和代谢特征
MedComm (2020). 2025 Jun 11;6(6):e70240. doi: 10.1002/mco2.70240. eCollection 2025 Jun.
7
A Cross-Sectional Study on Post-COVID-19 Menstrual Abnormalities in Women of Reproductive Age Group at a Tertiary Care Hospital.三级护理医院育龄期女性新冠病毒感染后月经异常的横断面研究
Obstet Gynecol Int. 2025 Mar 25;2025:1771858. doi: 10.1155/ogi/1771858. eCollection 2025.
8
Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的免疫和炎症后果及其在肾脏疾病中的意义。
Front Immunol. 2025 Feb 12;15:1376654. doi: 10.3389/fimmu.2024.1376654. eCollection 2024.
9
Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review.揭示2019冠状病毒病对卵巢功能和卵巢早衰的影响：一项系统综述
Biomedicines. 2025 Feb 7;13(2):407. doi: 10.3390/biomedicines13020407.
10
Alterations in menstrual characteristics and associated factors in Chinese women post SARS-CoV-2 infection: a cross-sectional study.新冠病毒感染后中国女性月经特征及相关因素的改变：一项横断面研究
BMC Womens Health. 2025 Feb 18;25(1):69. doi: 10.1186/s12905-025-03592-8.
113 例新冠肺炎死亡患者的临床特征：回顾性研究。
BMJ. 2020 Mar 26;368:m1091. doi: 10.1136/bmj.m1091.
4
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
5
Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
6
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.中国武汉 99 例 2019 年新型冠状病毒肺炎患者的流行病学和临床特征：描述性研究。
Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.
7
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
8
Pubertal abnormalities in adolescents with chronic disease.青少年慢性病患者的青春期异常。
Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101275. doi: 10.1016/j.beem.2019.04.009. Epub 2019 Apr 19.
9
Reproductive dysfunctions in viral hepatitis.病毒性肝炎中的生殖功能障碍。
Gynecol Endocrinol. 2016 Oct;32(sup2):37-40. doi: 10.1080/09513590.2016.1232780.
10
Role of cortisol and superoxide dismutase in psychological stress induced anovulation.皮质醇和超氧化物歧化酶在心理应激诱导的无排卵中的作用。
Gen Comp Endocrinol. 2016 Jan 1;225:117-124. doi: 10.1016/j.ygcen.2015.09.010. Epub 2015 Sep 21.