一种介导自然杀伤细胞功能的克隆细胞系可抑制免疫球蛋白分泌。
A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion.
作者信息
Nabel G, Allard W J, Cantor H
出版信息
J Exp Med. 1982 Aug 1;156(2):658-63. doi: 10.1084/jem.156.2.658.
Abstract
We previously described a cloned cell line that combines information for a unique display of cell surface antigens and specialized function similar to activated natural killer (NK) cells. In addition to conventional cellular targets such as the YAC-1 and MBL-2 lymphomas, this cloned line also lysed lipopolysaccharide-activated B lymphocytes. To determine whether some NK cells can inhibit B cell function, we tested the ability of NK-like clones to suppress Ig secretion in vitro and in vivo. These cloned cells suppressed Ig secretion when they constituted as few as 0.2% of the total cell population and inhibition did not require identity at the H-2 locus. We suggest that some NK cells might recognize non-major histocompatibility complex gene products on activated B lymphocytes and lyse these cells, and this might represent a fundamental cell-cell interaction that regulates antibody secretion by activated B cells.
摘要
我们之前描述过一种克隆细胞系，它整合了独特的细胞表面抗原展示信息以及与活化自然杀伤（NK）细胞相似的特殊功能。除了诸如YAC-1和MBL-2淋巴瘤等传统细胞靶点外，该克隆细胞系还能裂解脂多糖活化的B淋巴细胞。为了确定某些NK细胞是否能抑制B细胞功能，我们测试了类NK克隆在体外和体内抑制Ig分泌的能力。当这些克隆细胞在总细胞群体中所占比例低至0.2%时就能抑制Ig分泌，而且这种抑制并不需要H-2位点相同。我们认为，某些NK细胞可能识别活化B淋巴细胞上的非主要组织相容性复合体基因产物并裂解这些细胞，这可能代表了一种调节活化B细胞抗体分泌的基本细胞间相互作用。
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