通过中枢神经系统感染了解神经炎症。
Understanding neuroinflammation through central nervous system infections.
机构信息
Neuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA.
Neuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, USA; Department of Neurology, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA.
出版信息
Curr Opin Neurobiol. 2022 Oct;76:102619. doi: 10.1016/j.conb.2022.102619. Epub 2022 Aug 16.
Neuroinflammation is now recognized to compound many central nervous system (CNS) pathologies, from stroke to dementia. As immune responses evolved to handle infections, studying CNS infections can offer unique insights into the CNS immune response and address questions such as: What defenses and strategies do CNS parenchymal cells deploy in response to a dangerous pathogen? How do CNS cells interact with each other and infiltrating immune cells to control microbes? What pathways are beneficial for the host or for the pathogen? Here, we review recent studies that use CNS-tropic infections in combination with cutting-edge techniques to delve into the complex relationships between microbes, immune cells, and cells of the CNS.
神经炎症现在被认为是多种中枢神经系统（CNS）疾病的病因，包括中风和痴呆。由于免疫反应的进化是为了应对感染，因此研究中枢神经系统感染可以为中枢神经系统免疫反应提供独特的见解，并解决诸如以下问题：中枢实质细胞在应对危险病原体时会部署哪些防御和策略？中枢细胞如何与其他细胞相互作用以及浸润免疫细胞来控制微生物？哪些途径对宿主有益，哪些对病原体有益？在这里，我们回顾了最近的研究，这些研究使用了中枢神经系统趋向性感染，并结合了尖端技术，深入研究了微生物、免疫细胞和中枢神经系统细胞之间的复杂关系。
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