Diallo A, Barrett T, Lefevre P C, Taylor W P
J Gen Virol. 1987 Jul;68 ( Pt 7):2033-8. doi: 10.1099/0022-1317-68-7-2033.
The two morbilliviruses rinderpest virus (RPV) and peste des petits ruminants virus (PPRV) are closely related and cause severe disease in large and small ruminants, respectively. They show distinct epidemiological patterns and are distinguishable by reciprocal cross-neutralization tests. We have analysed the proteins induced by these viruses in infected cells and have shown that they can be distinguishable by a very marked difference in the apparent mol. wt. of the nucleocapsid (N) protein. The N protein of PPRV is almost identical in mobility on polyacrylamide gels to the N proteins of measles virus and canine distemper virus (60K). Several strains of RPV and PPRV from widespread geographical locations were studied and found to show this difference in the N protein.
两种麻疹病毒，即牛瘟病毒（RPV）和小反刍兽疫病毒（PPRV）关系密切，分别在大反刍动物和小反刍动物中引发严重疾病。它们呈现出不同的流行病学模式，可通过交叉中和试验加以区分。我们分析了这些病毒在受感染细胞中诱导产生的蛋白质，结果表明，它们可通过核衣壳（N）蛋白表观分子量的显著差异来区分。PPRV的N蛋白在聚丙烯酰胺凝胶上的迁移率与麻疹病毒和犬瘟热病毒的N蛋白（60K）几乎相同。对来自广泛地理位置的数株RPV和PPRV进行了研究，发现它们的N蛋白存在这种差异。
