Center for Biomedical Imaging, Department of Radiology, New York University Grossman School Medicine, 660 1st Avenue, 4th floor, New York, NY, 10016, USA.
Vilcek Institute of Graduate Biomedical Sciences, NYU Langone Health, New York, NY, 10016, USA.
Sci Rep. 2022 Aug 19;12(1):14156. doi: 10.1038/s41598-022-18388-1.
Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their combined use in a single experiment. In this work, we assessed the repeatability of normalized proton density (PD), T, T, and normalized sodium density-weighted quantification measured with simultaneous 3D H MRF/Na MRI in the brain at 7 T, from ten healthy volunteers who were scanned three times each. The coefficients of variation (CV) and the intra-class correlation (ICC) were calculated for the mean and standard deviation (SD) of these 4 parameters in grey matter, white matter, and cerebrospinal fluid. As result, the CVs were lower than 3.3% for the mean values and lower than 6.9% for the SD values. The ICCs were higher than 0.61 in all 24 measurements. We conclude that the measurements of normalized PD, T, T, and normalized sodium density-weighted from simultaneous 3D H MRF/Na MRI in the brain at 7 T showed high repeatability. We estimate that changes > 6.6% (> 2 CVs) in mean values of both H and Na metrics could be detectable with this method.
质子 MRI 可以提供详细的形态学图像，但它提供的关于细胞内稳态的信息很少。另一方面，钠 MRI 可以提供代谢信息，但不能解析精细结构。质子和钠 MRI 的互补性使得它们在单个实验中联合使用的前景变得更加光明。在这项工作中，我们评估了在 7T 下，来自 10 位健康志愿者的三次扫描，使用同步 3D H MRF/Na MRI 对大脑进行归一化质子密度 (PD)、T1、T2 和归一化钠密度加权定量测量的重复性。我们计算了灰质、白质和脑脊液中这 4 个参数的平均值和标准差 (SD) 的变异系数 (CV) 和组内相关系数 (ICC)。结果，平均值的 CV 低于 3.3%，标准差的 CV 低于 6.9%。在所有 24 次测量中，ICC 均高于 0.61。我们得出结论，在 7T 下，使用同步 3D H MRF/Na MRI 对大脑进行归一化 PD、T1、T2 和归一化钠密度加权定量测量具有很高的重复性。我们估计，使用这种方法可以检测到 H 和 Na 指标的平均值变化超过 6.6%（超过 2 个 CV）。
