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单一血管闭塞和再通过程中长时程小胶质细胞相特异性动力学。

Long-term microglial phase-specific dynamics during single vessel occlusion and recanalization.

机构信息

Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, China.

出版信息

Commun Biol. 2022 Aug 19;5(1):841. doi: 10.1038/s42003-022-03784-0.

DOI:10.1038/s42003-022-03784-0
PMID:35986097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9391347/
Abstract

Vascular occlusion leading to brain dysfunctions is usually considered evoking microglia-induced inflammation response. However, it remains unclear how microglia interact with blood vessels in the development of vascular occlusion-related brain disorders. Here, we illuminate long-term spatiotemporal dynamics of microglia during single vessel occlusion and recanalization. Microglia display remarkable response characteristics in different phases, including acute reaction, rapid diffusion, transition and chronic effect. Fibrinogen-induced microglial cluster promotes major histocompatibility complex II (MHCII) expression. Microglial soma represents a unique filament-shape migration and has slower motility compared to the immediate reaction of processes to occlusion. We capture proliferative microglia redistribute territory. Microglial cluster resolves gradually and microglia recover to resting state both in the morphology and function in the chronic effect phase. Therefore, our study offers a comprehensive analysis of spatiotemporal dynamics of microglia and potential mechanisms to both vessel occlusion and recanalization. Microglial phase-specific response suggests the morphological feature-oriented phased intervention would be an attractive option for vascular occlusion-related diseases treatments.

摘要

血管阻塞导致脑功能障碍通常被认为会引发小胶质细胞引发的炎症反应。然而，小胶质细胞在血管阻塞相关脑疾病的发展过程中如何与血管相互作用仍不清楚。在这里，我们揭示了单一血管阻塞和再通过程中小胶质细胞的长期时空动力学。小胶质细胞在不同阶段表现出显著的反应特征，包括急性反应、快速扩散、过渡和慢性效应。纤维蛋白原诱导的小胶质细胞簇促进主要组织相容性复合体 II（MHCII）的表达。小胶质细胞体呈现独特的丝状迁移，与突起对阻塞的即刻反应相比，其运动速度较慢。我们捕获到增殖的小胶质细胞重新分配领地。在慢性效应阶段，小胶质细胞簇逐渐消退，小胶质细胞在形态和功能上恢复到静息状态。因此，我们的研究提供了对小胶质细胞时空动力学及其对血管阻塞和再通的潜在机制的全面分析。小胶质细胞的阶段性反应表明，针对形态特征的阶段性干预可能是血管阻塞相关疾病治疗的一个有吸引力的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/36dd0d0f707f/42003_2022_3784_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/3afa1e87e897/42003_2022_3784_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/c80e7508a048/42003_2022_3784_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/033c14a05a5e/42003_2022_3784_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/e821fec114d1/42003_2022_3784_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/cd2e6ddd2b4d/42003_2022_3784_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/36dd0d0f707f/42003_2022_3784_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/3afa1e87e897/42003_2022_3784_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/be09e5fd4125/42003_2022_3784_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/f573c5c05cd4/42003_2022_3784_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/c80e7508a048/42003_2022_3784_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/033c14a05a5e/42003_2022_3784_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/e821fec114d1/42003_2022_3784_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/cd2e6ddd2b4d/42003_2022_3784_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db93/9391347/36dd0d0f707f/42003_2022_3784_Fig8_HTML.jpg

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本文引用的文献

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