Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Division of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei, 230026, China.
J Nanobiotechnology. 2022 Aug 19;20(1):381. doi: 10.1186/s12951-022-01559-7.
Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection.
生物活性材料被广泛开发用于癌症的辅助治疗。然而，由于大量出血和高复发率，很少有材料能够满足肝细胞癌 (HCC) 术后切除的要求。特别是，联合治疗 HCC 已在临床实践中得到高度推荐，包括手术切除、介入治疗、消融治疗和化疗。在此，通过临床可用的磁性蒙脱石和两性明胶纳米粒子之间的可控静电吸引作用，开发了一种可注射磁性胶体凝胶 (MCG)。优化后的 MCG 表现出有效的磁加热效应、显著的流变性能和高凝胶网络稳定性，通过响应性药物输送、止血和磁热疗实现了术后 HCC 的协同治疗。此外，在超声引导下实现了微创 MCG 诱导的介入磁热疗 (MHT)，为治疗术后复发提供了一种替代疗法。总的来说，MCG 是一种临床可用的 HCC 手术后辅助治疗的可注射制剂。
