Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P. R. China.
Department of General Surgery, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, P. R. China.
Small. 2024 Jan;20(3):e2300733. doi: 10.1002/smll.202300733. Epub 2023 Jul 14.
Relapse and unresectability have become the main obstacle for further improving hepatocellular carcinoma (HCC) treatment effect. Currently, single therapy for HCC in clinical practice is limited by postoperative recurrence, intraoperative blood loss and poor patient outcomes. Multidisciplinary therapy has been recognized as the key to improving the long-term survival rate for HCC. However, the clinical application of HCC synthetic therapy is restricted by single functional biomaterials. In this study, a magnetic nanocomposite hydrogel (CG-IM) with iron oxide nanoparticle-loaded mica nanosheets (Iron oxide nanoparticles@Mica, IM) is reported. This biocompatible magnetic hydrogel integrated high injectability, magnetocaloric property, mechanical robustness, wet adhesion, and hemostasis, leading to efficient HCC multidisciplinary therapies including postoperative tumor margin treatment and percutaneous locoregional ablation. After minimally invasive hepatectomy of HCC, the CG-IM hydrogel can facilely seal the bleeding hepatic margin, followed by magnetic hyperthermia ablation to effectively prevent recurrence. In addition, CG-IM hydrogel can inhibit unresectable HCC by magnetic hyperthermia through the percutaneous intervention under ultrasound guidance.
复发和不可切除性已成为进一步提高肝细胞癌（HCC）治疗效果的主要障碍。目前，临床实践中 HCC 的单一疗法受术后复发、术中出血和患者预后不良的限制。多学科治疗已被认为是提高 HCC 长期生存率的关键。然而，HCC 综合治疗的临床应用受到单一功能生物材料的限制。在本研究中，报道了一种具有负载氧化铁纳米颗粒的云母纳米片的磁性纳米复合水凝胶（CG-IM）。这种生物相容性磁性水凝胶集成了高可注射性、磁热特性、机械坚固性、湿附着力和止血性，可实现 HCC 多学科治疗，包括术后肿瘤边缘治疗和经皮局部消融。在 HCC 的微创肝切除术后，CG-IM 水凝胶可轻松密封出血的肝边缘，随后进行磁热疗消融以有效预防复发。此外，CG-IM 水凝胶可通过超声引导下的经皮介入通过磁热疗抑制不可切除的 HCC。
