抗 SOX1 抗体阳性小细胞肺癌引发的眼球震颤-肌阵挛。
Anti-SOX1 Antibody-positive Small-cell Lung Cancer That Triggered Opsoclonus.
机构信息
Department of Internal Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan.
Department of Respiratory Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan.
出版信息
Intern Med. 2023 Mar 15;62(6):881-884. doi: 10.2169/internalmedicine.0168-22. Epub 2022 Aug 20.
A 72-year-old woman with opsoclonus visited our hospital and was diagnosed with small-cell lung cancer. Blood tests revealed anti-SOX1 antibodies, so the patient was diagnosed with paraneoplastic opsoclonus-myoclonus syndrome. After steroid pulse therapy was started, chemotherapy of treatment, the opsoclonus showed an improving trend. Anti-Ri and anti-Hu antibodies have been reported as autoantibodies associated with neoplastic opsoclonus-myoclonus syndrome; however, there are no such reports concerning anti-SOX1 antibody. Therefore, this is a valuable case.
一位 72 岁的老年女性出现眼球震颤，来我院就诊，被诊断为小细胞肺癌。血液检查发现抗 SOX1 抗体，因此患者被诊断为副肿瘤性眼球震颤-肌阵挛综合征。开始使用类固醇脉冲疗法和化疗后，眼球震颤有改善趋势。抗 Ri 和抗 Hu 抗体已被报道为与肿瘤性眼球震颤-肌阵挛综合征相关的自身抗体；然而，关于抗 SOX1 抗体尚无此类报道。因此，这是一个有价值的病例。
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