Pincus T, Callahan L F, Vaughn W K
J Rheumatol. 1987 Apr;14(2):240-51.
Mortality over 9 years in rheumatoid arthritis was studied according to baseline demographic, disease, therapy and comorbidity variables, and measures of functional capacity variables. Significant differences between patients who survived and died over the next 9 years were seen for 8 variables: age, joint count, oral corticosteroid use, presence of concurrent heart disease, formal educational level, and 3 quantitative measures of functional capacity, questionnaire responses regarding activities of daily living, modified walking time and the button test. Five-year survivals of 50% or less were seen in patients with severely dysfunctional values for the 3 quantitative measures of functional capacity. Increased relative risk of mortality according to functional capacity measures was not explained by age, sex, duration of disease, smoking history, joint count, hand radiograph score, grip strength, morning stiffness, formal educational level, oral corticosteroid or parenteral gold use, or various comorbidities, and was not expected by a majority of physicians.
根据基线人口统计学、疾病、治疗和合并症变量以及功能能力变量的测量，对类风湿关节炎患者9年的死亡率进行了研究。在接下来9年内存活和死亡的患者之间，在8个变量上存在显著差异：年龄、关节计数、口服皮质类固醇的使用、并发心脏病的存在、正规教育水平以及功能能力的3项定量测量、关于日常生活活动的问卷回答、改良步行时间和纽扣试验。功能能力的3项定量测量值严重功能失调的患者，其5年生存率不到50%。根据功能能力测量得出的死亡率相对风险增加，无法用年龄、性别、病程、吸烟史、关节计数、手部X光片评分、握力、晨僵、正规教育水平、口服皮质类固醇或肠胃外金制剂的使用，或各种合并症来解释，并且大多数医生也未预料到这一点。
