Department of Gerontology and Geriatrics, The Second Hospital of Dalian Medical University, Dalian, China; Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Microvasc Res. 2022 Nov;144:104423. doi: 10.1016/j.mvr.2022.104423. Epub 2022 Aug 19.
Circulating insulin-like growth factor binding protein 2 (IGFBP-2) is associated with metabolic changes in both physiological and pathological conditions. The aim of this study was to investigate the correlation between IGFBP-2 related immunoreactivity in serum and arterial stiffness in a healthy Chinese population.
In this cross-sectional study, 360 healthy participants aged 37-87 years were recruited from 1500 and were divided into three groups according to serum IGFBP-2 related immunoreactivity (Tertile I, 25.437 ng/ml-120.870 ng/ml; Tertile II, 120.871 ng/ml-161.914 ng/ml; Tertile III, 161.915 ng/ml-321.636 ng/ml). Arterial stiffness was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI), and carotid intima-media thickness (cIMT). The association between IGFBP-2 related immunoreactivity and arterial stiffness was estimated by multiple stepwise regression.
Compared with the other two groups population, the individuals in Tertile I had significantly older age (62.66 ± 13.30 years, P < 0.01), lower level of triglyceride (1.08 ± 0.70 mmol/l, P < 0.01) and E/A (peak velocity of early filling and preak velocity of atrial filling ratio) (0.90 ± 0.33, P < 0.05). IGFBP-2 related immunoreactivity was inversely related with baPWV in the total population (r = -0.171, P < 0.01) and in Tertile I (r = -0.275, P < 0.01). After adjusting for age and the other confounders, no association was found between IGFBP-2 related immunoreactivity and baPWV in the total population. However, In Tertile I, reduced IGFBP-2 related immunoreactivity in serum was an independent risk factor of baPWV acceleration in three different adjustment models: Model 1 (no adjustment, P < 0.01), Model 2 (adjusted for age, P < 0.05), and Model 3 (adjusted for all variables, P < 0.05).
IGFBP-2 related immunoreactivity in serum is inversely associated with baPWV in a healthy Chinese population. This association did not change after adjustment for conventional risk factors for cardiovascular diseases in the subjects with the lowest IGFBP-2 related immunoreactivity. Consequently, reduction of IGFBP-2 related immunoreactivity may be a predictor of arterial stiffness. IGFBP-2 seems to be a potential intervention target in early atherosclerosis.
循环胰岛素样生长因子结合蛋白 2（IGFBP-2）与生理和病理条件下的代谢变化有关。本研究旨在探讨健康中国人群中血清 IGFBP-2 相关免疫反应与动脉僵硬之间的相关性。
在这项横断面研究中，从 1500 名参与者中招募了 360 名年龄在 37-87 岁的健康参与者，并根据血清 IGFBP-2 相关免疫反应将其分为三组（第 1 三分位数，25.437ng/ml-120.870ng/ml；第 2 三分位数，120.871ng/ml-161.914ng/ml；第 3 三分位数，161.915ng/ml-321.636ng/ml）。通过测量肱踝脉搏波速度（baPWV）、踝臂指数（ABI）和颈动脉内膜中层厚度（cIMT）来评估动脉僵硬。通过多元逐步回归估计 IGFBP-2 相关免疫反应与动脉僵硬之间的关联。
与其他两组人群相比，第 1 三分位数的个体年龄明显更大（62.66±13.30 岁，P<0.01），甘油三酯水平更低（1.08±0.70mmol/l，P<0.01）和 E/A（早期充盈峰值速度和心房充盈峰值速度比）（0.90±0.33，P<0.05）。IGFBP-2 相关免疫反应与总人群中的 baPWV 呈负相关（r=-0.171，P<0.01）和第 1 三分位数（r=-0.275，P<0.01）。在调整年龄和其他混杂因素后，IGFBP-2 相关免疫反应与总人群中的 baPWV 之间无关联。然而，在第 1 三分位数中，血清中 IGFBP-2 相关免疫反应的降低是 baPWV 加速的独立危险因素，在三种不同的调整模型中均如此：模型 1（未调整，P<0.01）、模型 2（调整年龄，P<0.05）和模型 3（调整所有变量，P<0.05）。
在中国健康人群中，血清中 IGFBP-2 相关免疫反应与 baPWV 呈负相关。在最低 IGFBP-2 相关免疫反应的受试者中，对心血管疾病的常规危险因素进行调整后，这种关联没有改变。因此，IGFBP-2 相关免疫反应的降低可能是动脉僵硬的预测指标。IGFBP-2 似乎是早期动脉粥样硬化的潜在干预靶点。
