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铕/钆共掺杂氟磷灰石纳米晶体的水热合成及体内荧光生物成像应用

Hydrothermal Synthesis and In Vivo Fluorescent Bioimaging Application of Eu/Gd Co-Doped Fluoroapatite Nanocrystals.

作者信息

Gedara Sriyani Menike Korale, Ding Zi-You, Balasooriya Iresha Lakmali, Han Yingchao, Wickramaratne Merita Nirmali

机构信息

State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.

Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Xianhu Hydrogen Valley, Foshan 528200, China.

出版信息

J Funct Biomater. 2022 Jul 29;13(3):108. doi: 10.3390/jfb13030108.

DOI:10.3390/jfb13030108
PMID:35997446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9397069/
Abstract

In this study, Eu/Gd co-doped fluoroapatitååe (Eu/Gd:FAP) nanocrystals were synthesized by the hydrothermal method as a fluorescent bioimaging agent. The phase composition, morphology, fluorescence, and biosafety of the resulting samples were characterized. Moreover, the in vivo fluorescent bioimaging application of Eu/Gd:FAP nanocrystals was evaluated in mice with subcutaneously transplanted tumors. The results showed that the Eu/Gd:FAP nanocrystals were short rod-like particles with a size of 59.27 ± 13.34 nm × 18.69 ± 3.32 nm. With an increasing F substitution content, the Eu/Gd:FAP nanocrystals displayed a decreased size and enhanced fluorescence emission. Eu/Gd:FAP nanocrystals did not show hemolysis and cytotoxicity, indicating good biocompatibility. In vivo fluorescent bioimaging study demonstrated that Eu/Gd:FAP nanocrystals could be used as a bioimaging agent and displayed stable fluorescence emitting in tumors, indicating an accumulation in tumor tissue due to the passive targeting ability. In addition, any adverse effects of Eu/Gd:FAP nanocrystals on major organs were not observed. This study shows that biocompatible rare earth co-doped FAP nanocrystals have the potential to be used as a bioimaging agent in vivo.

摘要

在本研究中，通过水热法合成了铕/钆共掺杂氟磷灰石（Eu/Gd:FAP）纳米晶体作为荧光生物成像剂。对所得样品的相组成、形态、荧光和生物安全性进行了表征。此外，在皮下移植肿瘤的小鼠中评估了Eu/Gd:FAP纳米晶体的体内荧光生物成像应用。结果表明，Eu/Gd:FAP纳米晶体为短棒状颗粒，尺寸为59.27±13.34 nm×18.69±3.32 nm。随着F取代含量的增加，Eu/Gd:FAP纳米晶体尺寸减小，荧光发射增强。Eu/Gd:FAP纳米晶体未表现出溶血和细胞毒性，表明具有良好的生物相容性。体内荧光生物成像研究表明，Eu/Gd:FAP纳米晶体可作为生物成像剂，在肿瘤中显示出稳定的荧光发射，表明由于被动靶向能力而在肿瘤组织中积累。此外，未观察到Eu/Gd:FAP纳米晶体对主要器官有任何不良影响。本研究表明，具有生物相容性的稀土共掺杂FAP纳米晶体有潜力在体内用作生物成像剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/2dafa0883ae2/jfb-13-00108-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/9f540b492ba2/jfb-13-00108-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/23cd616174d3/jfb-13-00108-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/25a3642f14b1/jfb-13-00108-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/6fd977603974/jfb-13-00108-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/0bc250dd8dd4/jfb-13-00108-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/c2e00de93ae6/jfb-13-00108-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/dba5487bbe01/jfb-13-00108-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/628d029ae2ff/jfb-13-00108-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/2dafa0883ae2/jfb-13-00108-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/9f540b492ba2/jfb-13-00108-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/23cd616174d3/jfb-13-00108-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/25a3642f14b1/jfb-13-00108-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/6fd977603974/jfb-13-00108-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/0bc250dd8dd4/jfb-13-00108-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/c2e00de93ae6/jfb-13-00108-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/dba5487bbe01/jfb-13-00108-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/628d029ae2ff/jfb-13-00108-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/9397069/2dafa0883ae2/jfb-13-00108-g009.jpg

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