Neacsu Ionela Andreea, Stoica Alexandra Elena, Vasile Bogdan Stefan, Andronescu Ecaterina
Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu Street,Bucharest, 011061, Romania.
Nanomaterials (Basel). 2019 Feb 10;9(2):239. doi: 10.3390/nano9020239.
One new, promising approach in the medical field is represented by hydroxyapatite doped with luminescent materials for biomedical luminescence imaging. The use of hydroxyapatite-based luminescent materials is an interesting area of research because of the attractive characteristics of such materials, which include biodegradability, bioactivity, biocompatibility, osteoconductivity, non-toxicity, and their non-inflammatory nature, as well their accessibility for surface adaptation. It is well known that hydroxyapatite, the predominant inorganic component of bones, serves a substantial role in tissue engineering, drug and gene delivery, and many other biomedical areas. Hydroxyapatite, to the detriment of other host matrices, has attracted substantial attention for its ability to bind to luminescent materials with high efficiency. Its capacity to integrate a large assortment of substitutions for Ca, PO₄, and/or OH ions is attributed to the versatility of its apatite structure. This paper summarizes the most recently developed fluorescent materials based on hydroxyapatite, which use rare earth elements (REEs) as dopants, such as terbium (Tb), erbium (Er), europium (Eu), lanthanum (La), or dysprosium (Dy), that have been developed in the biomedical field.
医学领域一种新的、有前景的方法是使用掺杂发光材料的羟基磷灰石进行生物医学发光成像。基于羟基磷灰石的发光材料的应用是一个有趣的研究领域，因为这类材料具有吸引人的特性，包括生物可降解性、生物活性、生物相容性、骨传导性、无毒性及其非炎性本质，以及它们易于进行表面改性。众所周知，羟基磷灰石作为骨骼的主要无机成分，在组织工程、药物和基因递送以及许多其他生物医学领域发挥着重要作用。与其他主体基质不同，羟基磷灰石因其能够高效结合发光材料而备受关注。其整合大量Ca、PO₄和/或OH离子替代物的能力归因于其磷灰石结构的多功能性。本文总结了基于羟基磷灰石的最新开发的荧光材料，这些材料使用稀土元素（REEs）作为掺杂剂，如铽（Tb）、铒（Er）、铕（Eu）、镧（La）或镝（Dy），它们已在生物医学领域得到开发。
