State Key Laboratory of Transient Optics and Photonics, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Science (CAS), Xi'an, Shaanxi, PR China.
University of Chinese Academy of Sciences (UCAS), Beijing, PR China.
J Biomater Appl. 2020 Aug;35(2):237-263. doi: 10.1177/0885328220924540. Epub 2020 May 19.
Rare earth-doped nanoparticles have been widely used in disease diagnosis, drug delivery, tumor therapy, and bioimaging. Among various bioimaging methods, the fluorescence imaging technology based on the rare earth-doped nanoparticles can visually display the cell activity and lesion evolution in living animals, which is a powerful tool in biological technology and has being widely applied in medical and biological fields. Especially in the band of near infrared (700-1700 nm), the emissions show the characteristics of deep penetration due to low absorption, low photon scattering, and low autofluorescence interference. Furthermore, the rare earth-doped nanoparticles can be endowed with the water solubility, biocompatibility, drug-loading ability, and the targeting ability for different tumors by surface functionalization. This confirms its potential in the cancer diagnosis and treatment. In this review, we summarized the recent progress in the application of rare earth-doped nanoparticles in the field of bioimaging and tumor treatment. The luminescent mechanism, properties, and structure design were also discussed.
稀土掺杂纳米粒子已被广泛应用于疾病诊断、药物输送、肿瘤治疗和生物成像。在各种生物成像方法中，基于稀土掺杂纳米粒子的荧光成像技术可以直观地显示活体内细胞的活性和病变演变，是生物技术的有力工具，已广泛应用于医学和生物学领域。特别是在近红外波段（700-1700nm），由于低吸收、低光子散射和低自发荧光干扰，其发射具有深穿透的特点。此外，通过表面功能化，稀土掺杂纳米粒子可以赋予其不同肿瘤的水溶性、生物相容性、载药能力和靶向能力。这证实了其在癌症诊断和治疗方面的潜力。本文总结了稀土掺杂纳米粒子在生物成像和肿瘤治疗领域的最新应用进展，讨论了其发光机制、性能和结构设计。
