Srebro Dragana, Rajković Katarina, Dožić Branko, Vujović Katarina Savić, Brkić Branislava Medić, Milić Petar, Vučković Sonja
Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Department of Kruševac, Academy of Educational and Medical Vocational Studies, Krusevac, Serbia.
Dose Response. 2022 Aug 17;20(3):15593258221119877. doi: 10.1177/15593258221119877. eCollection 2022 Jul-Sep.
leaf is obtained from a plant that is used in traditional medicine in some countries to alleviate inflammatory diseases.
The aim of this study was to compare the effects of extract on acute nociceptive and inflammatory pain in rats.
Antinociceptive activity was examined in Wistar rats by the tail-immersion and formalin tests. Motor function was assessed using the rotarod test. Plant extract was administered intraperitoneally.
In the tail-immersion test, the maximal antinociceptive effect of the plant extract (100-330 mg/kg) was about 24-30% and is the result of the effect of a high concentration of ethanol. In the formalin test, the plant extract (41.3-330 mg/kg) significantly and dose-dependently inhibited nociception in both phases of the test with similar maximal effects of about 76% and 85%. Only the plant extract at the dose of 330 mg/kg caused a significant time-dependent reduction in time spent on the rotarod.
In rats, the preventive systemic administration of the hydroethanolic extract of leaf reduced chemically but not thermally induced pain. Higher efficacy was obtained in pain associated with inflammation and tissue injury. The antinociceptive effect is dose-dependent and may be limited by motor impairment.
叶取自一种植物，在一些国家的传统医学中用于缓解炎症性疾病。
本研究旨在比较叶提取物对大鼠急性伤害性和炎性疼痛的影响。
通过尾部浸没法和福尔马林试验在Wistar大鼠中检测抗伤害感受活性。使用转棒试验评估运动功能。腹腔注射植物提取物。
在尾部浸没法试验中，植物提取物（100 - 330毫克/千克）的最大抗伤害感受作用约为24 - 30%，这是高浓度乙醇作用的结果。在福尔马林试验中，植物提取物（41.3 - 330毫克/千克）在试验的两个阶段均显著且剂量依赖性地抑制伤害感受，最大作用相似，约为76%和85%。仅330毫克/千克剂量的植物提取物导致在转棒上花费的时间出现显著的时间依赖性减少。
在大鼠中，预防性全身给予叶的水乙醇提取物可减轻化学性而非热性诱导的疼痛。在与炎症和组织损伤相关的疼痛中获得了更高的疗效。抗伤害感受作用是剂量依赖性的，并且可能受到运动功能损害的限制。
