Department of Pharmacy, Federal University of Alfenas-MG, Alfenas, Minas Gerais, Brazil.
J Med Food. 2009 Dec;12(6):1381-5. doi: 10.1089/jmf.2009.0012.
Morus nigra has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of dichloromethane extract from leaves of M. nigra. The formalin, hot plate, and tail immersion tests as well as acetic acid-induced writhing were used to investigate the antinociceptive activity in mice. The extract at test doses of 100 and 300 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract administered at 300 mg/kg, p.o. had a stronger antinociceptive effect than indomethacin (5 mg/kg, p.o.) and morphine (10 mg/kg, p.o.), which supports previous claims for its traditional use.
桑叶在巴西民间医学中被用于缓解疼痛。本研究旨在确定桑叶二氯甲烷提取物的镇痛特性。甲醛、热板和尾部浸入试验以及醋酸诱导的扭体试验用于研究小鼠的镇痛活性。提取物在测试剂量为 100 和 300 mg/kg，po 时，在所有试验中均表现出明显的镇痛活性。与吲哚美辛（5mg/kg，po）和吗啡（10mg/kg，po）相比，300mg/kg，po 给予提取物具有更强的镇痛作用，这支持了其传统用途的说法。
