de Carvalho Carla C C R
iBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
Bioengineering (Basel). 2022 Jul 30;9(8):355. doi: 10.3390/bioengineering9080355.
The increasing number of life-threatening infections observed in cancer patients has been ascribed to chemotherapy-induced neutropenia and to invasive medical procedures such as surgery and the application of catheters. In this study, it was questioned if the infections could also be favored by an increased resistance of bacteria due to the adaptation to antineoplastic agents used in chemotherapy. After exposure to several antineoplastic agents, it was observed that cells of , , and changed the fatty acid profile of their cellular membranes, produced exopolymeric substances, and formed aggregates that adhered to surfaces. Additionally, when exposed to high concentrations of these compounds, a persister sub-population could be identified. After adaptation to antineoplastic agents, the minimum inhibitory concentration (MIC) of several antibiotics increased considerably in the tested strains.
癌症患者中观察到的危及生命的感染数量不断增加，这归因于化疗引起的中性粒细胞减少以及手术和导管应用等侵入性医疗程序。在本研究中，有人质疑感染是否也可能因细菌对化疗中使用的抗肿瘤药物产生适应性而导致耐药性增加而受到促进。在接触几种抗肿瘤药物后，观察到[具体细菌名称1]、[具体细菌名称2]、[具体细菌名称3]和[具体细菌名称4]的细胞改变了其细胞膜的脂肪酸谱，产生了胞外聚合物，并形成了附着在表面的聚集体。此外，当暴露于这些化合物的高浓度时，可以识别出一个持留菌亚群。在适应抗肿瘤药物后，测试菌株中几种抗生素的最低抑菌浓度（MIC）显著增加。
