Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Wuhan National Laboratory for Optoelectronics (WNLO), Huazhong University of Science and Technology (HUST), Wuhan 430074, China.
Biosensors (Basel). 2022 Aug 11;12(8):629. doi: 10.3390/bios12080629.
With the current trend of device miniaturization, the measurement and control of interfacial adhesion forces are increasingly important in fields such as biomechanics and cell biology. However, conventional fiber optic force sensors with high Young’s modulus (>70 GPa) are usually unable to measure adhesion forces on the micro- or nano-Newton level on the surface of micro/nanoscale structures. Here, we demonstrate a method for interfacial adhesion force measurement in micro/nanoscale structures using a fiber-tip microforce sensor (FTMS). The FTMS, with microforce sensitivity of 1.05 nm/μN and force resolution of up to 19 nN, is fabricated using femtosecond laser two-photon polymerization nanolithography to program a clamped-beam probe on the end face of a single-mode fiber. As a typical verification test, the micronewton-level contact and noncontact adhesion forces on the surfaces of hydrogels were measured by FTMS. In addition, the noncontact adhesion of human hair was successfully measured with the sensor.
随着器件微型化的当前趋势，界面粘附力的测量和控制在生物力学和细胞生物学等领域变得越来越重要。然而，传统的具有高杨氏模量（>70 GPa）的光纤力传感器通常无法测量微/纳米尺度结构表面上的微/纳牛顿级的粘附力。在这里，我们展示了一种使用光纤尖端微力传感器（FTMS）测量微/纳米尺度结构中的界面粘附力的方法。FTMS 使用飞秒激光双光子聚合纳米光刻技术制造，在单模光纤的端面上编程了一个夹紧梁探头，具有 1.05nm/μN 的微力灵敏度和高达 19nN 的力分辨率。作为典型的验证测试，通过 FTMS 测量了水凝胶表面的微牛顿级接触和非接触粘附力。此外，还成功地用传感器测量了人发的非接触粘附力。
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