Murray Ben, Blacklock Kelly L Bowlt
Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
Vet Sci. 2022 Aug 9;9(8):421. doi: 10.3390/vetsci9080421.
Measurement of blood biomarkers such as lactate dehydrogenase (LDH) and peripheral leukocyte ratios have been shown to be of prognostic value in human melanoma patients. Previous veterinary studies have demonstrated that changes in these values are detectable in multiple canine cancer patients. However, to the authors’ knowledge, no studies have yet demonstrated an increase in LDH in canine oral malignant melanoma patients, nor has the effect of metastasis on LDH levels been explored. This retrospective pilot study included 18 dogs, of which 10 were healthy controls, 5 OMM patients with metastasis and 3 without metastasis. Serum LDH was measured and pre-treatment peripheral leucocyte ratios were calculated. LDH was measurable within all patient groups and a statistically significant difference in LDH levels was detected between patients with OMM and healthy controls (p < 0.05); however, no significant difference was detected between patients with or without metastatic disease. This study suggests that serum LDH levels are significantly increased in dogs with OMM compared to healthy controls, paving the way for further research to investigate the prognostic value of this biomarker.
血液生物标志物如乳酸脱氢酶（LDH）的测量以及外周白细胞比率已被证明对人类黑色素瘤患者具有预后价值。先前的兽医研究表明，在多位犬类癌症患者中可检测到这些值的变化。然而，据作者所知，尚无研究表明犬口腔恶性黑色素瘤患者的LDH升高，也未探讨转移对LDH水平的影响。这项回顾性试点研究纳入了18只犬，其中10只为健康对照，5只患有转移的口腔恶性黑色素瘤（OMM）患者和3只无转移的患者。测量了血清LDH并计算了治疗前外周白细胞比率。所有患者组中均可测量LDH，并且在OMM患者与健康对照之间检测到LDH水平存在统计学显著差异（p < 0.05）；然而，在有或无转移性疾病的患者之间未检测到显著差异。这项研究表明，与健康对照相比，患有OMM的犬的血清LDH水平显著升高，为进一步研究该生物标志物的预后价值铺平了道路。
