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与人类热休克蛋白70（hsp70）启动子结合的热诱导人类因子。

Heat-inducible human factor that binds to a human hsp70 promoter.

作者信息

Kingston R E, Schuetz T J, Larin Z

出版信息

Mol Cell Biol. 1987 Apr;7(4):1530-4. doi: 10.1128/mcb.7.4.1530-1534.1987.

DOI:10.1128/mcb.7.4.1530-1534.1987
PMID:3600634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365241/
Abstract

A factor found in nuclear extracts of human cells bound to the heat shock element of a human heat shock protein 70 gene. The level of this factor was significantly increased after heat shock. This induction was rapid and was not blocked by cycloheximide, suggesting that an initial event in the response of a human cell to heat is the activation of a preexisting regulatory factor.

摘要

在人类细胞的核提取物中发现一种与人类热休克蛋白70基因的热休克元件结合的因子。热休克后该因子的水平显著升高。这种诱导迅速，且不受环己酰亚胺的阻断，这表明人类细胞对热反应的初始事件是一种预先存在的调节因子的激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/6d40f43a21ea/molcellb00076-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/34eedd16d5a3/molcellb00076-0229-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/292c8263d1b8/molcellb00076-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/29170ae70de7/molcellb00076-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/6d40f43a21ea/molcellb00076-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/34eedd16d5a3/molcellb00076-0229-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/292c8263d1b8/molcellb00076-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/29170ae70de7/molcellb00076-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/941f/365241/6d40f43a21ea/molcellb00076-0231-b.jpg

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