Léonard A, Lauwerys R
Mutat Res. 1987 Jul;186(1):35-42. doi: 10.1016/0165-1110(87)90013-3.
The carcinogenicity of a number of beryllium compounds has been confirmed in experiments on laboratory animals and this metal has to be treated as a possible carcinogenic threat to man. These carcinogenic properties are associated with mutagenic activity as shown by the results of short-term tests performed in vitro with beryllium chloride and beryllium sulfate. These soluble beryllium compounds can produce some infidelity of in vitro synthesis, forward gene mutations in microorganisms and in mammalian cells. They are also able to induce cell transformation. In addition to the positive results obtained in several short-term assays beryllium compounds have been found to bind to nucleoproteins, to inhibit certain enzymes needed for DNA synthesis, to bind nucleic acids to cell membranes and to inhibit microtubule polymerization. The teratogenicity of beryllium salts is relatively unknown and needs additional investigation.
多种铍化合物的致癌性已在实验动物实验中得到证实，这种金属必须被视为对人类可能的致癌威胁。这些致癌特性与诱变活性有关，如用氯化铍和硫酸铍进行的体外短期试验结果所示。这些可溶性铍化合物可导致体外合成出现一些差错、微生物和哺乳动物细胞中的正向基因突变。它们还能够诱导细胞转化。除了在多个短期试验中获得的阳性结果外，还发现铍化合物可与核蛋白结合、抑制DNA合成所需的某些酶、使核酸与细胞膜结合并抑制微管聚合。铍盐的致畸性相对未知，需要进一步研究。
